碳酸氢钠联合维生素C应用于冠心病合并早期DN患者PCI术后的效果分析  

Effect analysis of sodium bicarbonate combined with vitamin C in patients with coronary heart disease and early DN after PCI

作　　者：潘婉娟 黄莉青 PAN Wan-juan;HUANG Li-qing(Department of Critical Care Medicine,People’s Hospital of Xuwen County,Zhanjiang 524100,China)

机构地区：[1]广东省徐闻县人民医院重症医学科,524100 [2]广东省徐闻县人民医院检验科,524100

出　　处：《中国实用医药》2021年第34期120-122,共3页China Practical Medicine

摘　　要：目的探讨碳酸氢钠联合维生素C应用于冠心病合并早期糖尿病肾病(DN)患者经皮冠状动脉介入治疗(PCI)术后的效果。方法108例冠心病合并早期DN患者,随机分为对照组和观察组,每组54例。对照组予以碳酸氢钠治疗,观察组给予碳酸氢钠联合维生素C治疗。比较两组治疗效果、治疗前后临床指标、不良反应发生情况。结果观察组总有效率94.44%高于对照组的81.48%,差异具有统计学意义(P<0.05)。治疗后,两组患者总胆固醇(TC)、尿素氮(BUN)水平均较治疗前下降,且观察组TC(5.71±0.41)mmol/L、BUN(20.51±3.28)mmol/L均低于对照组的(9.32±1.34)、(24.09±3.87)mmol/L,差异均具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(χ^(2)=0.153,P<0.05)。结论冠心病合并早期DN患者PCI术后使用碳酸氢钠联合维生素C的疗效显著,可缓解肾功能损伤,不会增加不良反应的发生。Objective To discuss the effect of sodium bicarbonate combined with vitamin C in patients with coronary heart disease and early diabetic nephropathy(DN)after percutaneous coronary intervention(PCI).Methods A total of 108 patients with coronary heart disease and early DN were randomly divided into control group and observation group,with 54 cases in each group.The control group was treated with sodium bicarbonate,and the observation group was treated with sodium bicarbonate and vitamin C.The therapeutic effects,clinical indicators before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate 94.44%of the observation group was higher than 81.48%of the control group,and the difference was statistically significant(P<0.05).After treatment,the total cholesterol(TC)and blood urea nitrogen(BUN)levels of the two groups were lower than those of this group before treatment,and the TC(5.71±0.41)mmol/L and BUN(20.51±3.28)mmol/L of the observation group were lower than(9.32±1.34)and(24.09±3.87)mmol/L of the control group.All the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ^(2)=0.153,P>0.05).Conclusion Sodium bicarbonate in combination with vitamin C has significant efficacy on patients with coronary heart disease and early DN after PCI,and it can alleviate renal function damage without increasing the occurrence of adverse reactions.

关 键 词：碳酸氢钠 维生素C 冠心病 早期糖尿病肾病 经皮冠状动脉介入治疗 

分 类 号：R541.4[医药卫生—心血管疾病] R587.2[医药卫生—内科学] R692.9[医药卫生—临床医学]