3-芳基喹喔啉-2(1H)-酮衍生物的合成研究进展  

Progress on the Synthesis of 3-Arylquinoxalin-2(1H)-one Derivatives

作　　者：宋华龙 劳红标 宋胜杰 周春松 SONG Hua-long;LAO Hong-biao;SONG Sheng-jie;ZHOU Chun-song(Shaoxing Water Treatment Development Co.,Ltd.,Shaoxing,Zhejiang 312030,China;College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China;International Environmental Protection City Technology Limited Company(IEPCT),Yixing,Jiangsu 214200,China;Southwest Academy,College of Chemical Engineering,Zhejiang University of Technology,Fuquan,Guizhou 550599,China)

机构地区：[1]绍兴水处理发展有限公司,浙江绍兴312030 [2]浙江工业大学药学院,浙江杭州310014 [3]宜兴国际环保城科技发展有限公司,江苏宜兴214200 [4]浙江工业大学化学工程学院西南研究院,贵州福泉550599

出　　处：《浙江化工》2021年第12期4-8,共5页Zhejiang Chemical Industry

摘　　要：喹喔啉-2(1H)-酮广泛存在于天然产物和生物活性化合物中,其中3-芳基喹喔啉-2(1H)-酮衍生物显示出优异的抗肿瘤、抗菌等生物活性,因此合成3-芳基取代喹喔啉-2(1H)-酮类化合物具有重要意义。本文从传统合成方法和C-H官能团化方法分别介绍了3-芳基喹喔啉-2(1H)-酮衍生物的合成研究进展。Quinoxaline-2(1H)-ones are widely exist in natural products and bioactive compounds.Among them,the 3-arylquinoxaline-2(1H)-one derivatives show excellent bioactivities such as antitumor agents and antibacterials.Therefore,the synthesis of 3-aryl substituted quinoxaline-2(1H)-one derivatives is of great significance.This paper introduced the progress in the synthesis of 3-arylquinoxaline-2(1H)-one derivatives from traditional methods and C-H functionalization methods separately.

关 键 词：喹喔啉-2(1H)-酮 芳基取代 传统合成方法 C-H官能团化 

分 类 号：O626[理学—有机化学]