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作 者:张立营[1,2] 陈朴 郑巧[1,2] 姜兰斌 唐世杰 ZHANG Liying;CHEN Pu;ZHENG Qiao;JIANG Lanbin;TANG Shijie(Department of Laboratory,the First People′s Hospital of Yibin,Yibin,Sichuan 644000,China;Department of Laboratory,Wuhan Red Cross Hospital,Wuhan,Hubei 430014,China;Department of Laboratory,the Second People′s Hospital of Yibin,Yibin,Sichuan 644000,China)
机构地区:[1]四川省宜宾市第一人民医院检验科,644000 [2]武汉红十字会医院检验科,430014 [3]四川省宜宾市第二人民医院检验科,644000
出 处:《重庆医学》2021年第24期4232-4236,共5页Chongqing medicine
摘 要:目的探讨武汉地区新型冠状病毒肺炎(COVID-19)患者的临床特征及实验室检测结果,为COVID-19防治提供依据。方法选取2020年1月28日至3月10日武汉红十字会医院收治的有完整病例信息的478例COVID-19患者,根据病情分为轻症组(轻型+普通型)和重症组(重型+危重型),比较两组COVID-19患者的临床特征及实验室检测结果变化情况。结果与轻症组患者相比,重症组患者年龄偏大,合并基础疾病比率(75.21%)较高,两组比较差异均有统计学意义(P<0.05)。与轻症组患者相比,重症组患者白细胞计数、中性粒细胞计数、中性粒细胞与淋巴细胞比值(NLR)、降钙素原、C反应蛋白(CRP)、白细胞介素-6(IL-6)、红细胞沉降率(ESR)、肌酸激酶、肌酸激酶同工酶、肌红蛋白、肌钙蛋白I、D-二聚体、纤维蛋白原和动脉血二氧化碳分压(PaCO_(2))升高明显,差异均有统计学意义(P<0.05)。与轻症组患者相比,重症组患者淋巴细胞计数、氧分压和血氧饱和度水平显著较低,差异均有统计学意义(P<0.05)。丙氨酸氨基转移酶(ALT)、尿素和肌酐等指标经两两比较差异均无统计学意义(P>0.05)。重症组患者合并甲型、乙型流感病毒或其他呼吸道病原体感染的阳性率与轻症组比较,差异均无统计学意义(P>0.05)。结论重症COVID-19患者一般年龄偏大,或伴有基础疾病,病毒感染和炎症反应更严重,容易出现心肌损伤等症状。因此应更加重视这类患者,及时准确监测实验室检测指标,预防病情加重。Objective To explore the clinical characteristics and laboratory test results of the patients with novel coronavirus disease 2019(COVID-19)in Wuhan,so as to provide evidence for COVID-19′s prevention and treatment.Methods A total of 478 COVID-19 patients with complete case information from Wuhan Red Cross Hospital from January 28 to March 10,2020 were selected.According to the disease condition,the patients were divided into the mild group(mild+ordinary type)and the severe group(severe+critical type).The clinical characteristics and laboratory test results of those patients with COVID-19 were compared between the two groups.Results The COVID-19 patients in the severe group were older and had a higher rate of underlying diseases(75.21%),compared with those in the mild group,and the difference was statistically significant(P<0.05).The severe group had the significant higher levels of WBC,NEUT,NLR,PCT,CRP,IL-6,ESR,CK,CK-MB,Mb,cTnI,D-D,Fib and PaCO_(2),compared with the mild group.All the differences were statistically significant(P<0.05).Compared with those of patients in the mild group,the levels of LYMPH,PO_(2) and SaO_(2)%of patients in the severe group were significantly lower,and the differences were statistically significant(P<0.05).There were no significant differences in other indexes such as ALT,Urea and Cr by pairwise comparison(P>0.05).The differences in the positive rate of influenza A,B virus or other respiratory pathogens between the groups were not statistically significant(P>0.05).Conclusion The patients with severe COVID-19 were generally older,or accompanied by underlying diseases.The viral infection and inflammation were more serious and prone to myocardial injury and other symptoms.Therefore,more attention should be paid to this kind of patients.To prevent the disease from getting worse,the laboratory testing indicators should be monitored timely and accurately.
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