山东省烟台市布鲁氏菌病发病状况调查及临床特征分析  

Incidence and clinical characteristics of brucellosis in Yantai City,Shandong Province

作　　者：包相华 毕珂 史懋功 Bao Xianghua;Bi Ke;Shi Maogong(Department of Occupational Diseases,Yantaishan Hospital,Yantai 264025,China)

机构地区：[1]山东省烟台市烟台山医院职业病科,264025

出　　处：《中华地方病学杂志》2021年第12期1017-1020,共4页Chinese Journal of Endemiology

摘　　要：目的探讨山东省烟台市布鲁氏菌病发病状况和临床特征, 为制定布鲁氏菌病防控策略提供参考依据。方法对2017年1月至2019年12月烟台市经中国疾病预防控制信息系统传染病报告信息管理系统报告的布鲁氏菌病病例进行描述流行病学分析, 同时, 对其危险因素暴露及临床特征等资料进行分析。结果 2017 - 2019年烟台市共报告225例布鲁氏菌病病例, 其中男性138例、女性87例, 男女性别比为1.59 ∶ 1.00;年龄为(43.25 ± 8.61)岁, 以30 ~ < 40岁最常见(80例);地区分布中, 以芝罘区最多(96例);发病时间主要集中在1 - 5月(147例)。布鲁氏菌病病例危险因素暴露中, 与动物或其产品有密切接触史共196例, 占87.11%(196/225)。布鲁氏菌病病例临床特征以发热(203例)、乏力(188例)、关节肌肉痛(184例)及多汗(148例)为主。225例布鲁氏菌病病例均为实验室诊断病例, 其中血清试管凝集试验滴度1 ∶ 100者56例, 占24.89%;1 ∶ 200者75例, 占33.33%;1 ∶ 400者94例, 占41.78%。随着滴度水平增高, 发热、多汗、关节肌肉痛、乏力发生率呈增高趋势, 差异均有统计学意义(P均<0.05)。结论烟台市布鲁氏菌病发病人群以中青年男性为主, 常见于有动物或其产品接触史人群, 临床表现缺少特异性。应对高危人群开展健康教育, 提高其自我防护意识, 同时加强布鲁氏菌病监测力度, 以减少布鲁氏菌病发生。Objective To investigate the incidence and clinical characteristics of brucellosis in Yantai City of Shandong Province,and to provide reference for formulating prevention and control strategies of brucellosis.Methods From January 2017 to December 2019,brucellosis cases reported by the Infectious Disease Reporting Information Management System of China Disease Prevention and Control Information System in Yantai City were analyzed,and their risk factors and clinical characteristics were analyzed.Results A total of 225 cases of brucellosis were reported in Yantai City from 2017 to 2019,including 138 males and 87 females,with a gender ratio of 1.59∶1.00;the age was(43.25±8.61)years,and the most common age was 30-<40 years(80 cases);in the regional distribution,Zhifu District was the most(96 cases);the onset time was mainly from January to May(147 cases).Among the risk factors of brucellosis cases,196 cases(87.11%,196/225)had close contact with animals or their products.The main clinical characteristics of brucellosis cases were fever(203 cases),fatigue(188 cases),arthralgia(184 cases)and hyperhidrosis(148 cases).All 225 cases of brucellosis were diagnosed in laboratory,including 56 cases(24.89%)with titer 1∶100 of serum tube agglutination test;75 cases(33.33%)with titer 1∶200;and 94 cases(41.78%)with titer 1∶400.With the increase of titer level,the incidence of fever,hyperhidrosis,arthralgia and fatigue increased,and the differences were statistically significant(P<0.05).Conclusions The incidence of brucellosis in Yantai City is mainly young and middle-aged males,which is common in people who have contact history with animals or their products,and the clinical manifestations are lack of specificity.Health education should be carried out among high-risk groups to improve their self-protection awareness,and brucellosis surveillance should be strengthened to reduce the incidence of brucellosis.

关 键 词：布鲁杆菌病 流行病学 临床特征 

分 类 号：R516.7[医药卫生—内科学]