自拟理肺化瘀方治疗支气管哮喘患者的临床效果  

Clinical effect of self-made Lifei Huayu Prescription in the teatment of bronchial asthma patients

作　　者：朱立成[1] 吴传中[2] 朱文娟[3] 尚云飞[1] ZHU Licheng;WU Chuanzhong;ZHU Wenjuan;SHANG Yunfei(Department of Pneumology,the Third People’s Hospital of Nantong City,Jiangsu Province,Nantong226000,China;Department of Geriatrics,the Third People’s Hospital of Nantong City,Jiangsu Province,Nantong226000,China;Department of Pneumology,Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Jiangxi Province,Nanchang330006,China)

机构地区：[1]江苏省南通市第三人民医院呼吸科,江苏南通226000 [2]江苏省南通市第三人民医院老年科,江苏南通226000 [3]江西中医药大学附属医院呼吸科,江西南昌330006

出　　处：《中国医药导报》2021年第36期127-130,共4页China Medical Herald

基　　金：江西省教育厅科学技术研究项目(GJJ170742)。

摘　　要：目的研究自拟理肺化瘀方治疗支气管哮喘患者的临床效果。方法选取2018年1月至2020年4月江苏省南通市第三人民医院收治的支气管哮喘患者80例,采用奇偶数分组法分为两组,每组40例。对照组给予基础治疗,观察组在对照组基础上给予自拟理肺化瘀方治疗,两组均连续治疗2周。比较两组疗效,观察两组哮喘控制测试表(ACT)评分及血清免疫球蛋白(Ig)、环磷酸腺苷(cAMP)、白细胞介素(IL)-10、IL-33的水平。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组ACT评分及血清内IgG、IgA、IgM、cAMP、IL-10、IL-33水平比较,差异无统计学意义(P>0.05),治疗后两组ACT评分及Ig、cAMP、IL-10水平较治疗前升高,IL-33水平较治疗前下降,且观察组治疗后ACT评分及Ig、cAMP、IL-10水平高于对照组,IL-33水平低于对照组,差异有统计学意义(P<0.05)。结论自拟理肺化瘀方可改善支气管哮喘患者免疫功能,调节cAMP、IL-10、IL-33水平,有效控制哮喘。Objective To study the clinical effect of self-made Lifei Huayu Prescription on bronchial asthma patients.Methods A total of 80 patients with bronchial asthma admitted to the Third People’s Hospital of Nantong City from January 2018 to April 2020 were selected and divided into two groups by odd and even grouping method,with 40 patients in each group.The control group was given basic treatment,and the observation group was given self-made Lifei Huayu Prescription on the basis of the control group.Both groups were given continuous treatment for two weeks.The efficacy of the two groups was compared.Asthma control test table(ACT)score and the serum levels of immunoglobulin(Ig),cyclic adenosine monophosphate(cAMP),interleukin(IL)-10,and IL-33 in both groups were observed.Results The total effective rate of observation group was higher than control group,and the difference was statistically significant(P<0.05).There were no significant differences in ACT score,serum IgG,IgA,IgM,cAMP,IL-10,and IL-33 levels between the two groups before treatment(P>0.05).After treatment,ACT score,Ig,cAMP,and IL-10 levels were increased compared with before treatment,while IL-33 level was decreased compared with before treatment in the two groups.After treatment,ACT score,Ig,cAMP,and IL-10 levels in the observation group were higher than those in the control group,while IL-33 level was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion Self-made Lifei Huayu Prescription can improve the immune function of bronchial asthma patients,regulate the levels of cAMP,IL-10,and IL-33,and effectively control asthma.

关 键 词：自拟理肺化瘀方剂 支气管哮喘 免疫球蛋白 环磷酸腺苷 

分 类 号：R562.2[医药卫生—呼吸系统]