基于纤维化的窦房结功能不全与心房颤动发病机制的研究进展  

Research progress on pathogenesis of sinoatrial node dysfunction and atrial fibrillation based on fibrosis

作　　者：张一丹 王贺[2] 司春婴[2] 曹英杰[3] 解金红[2] ZHANG Yidan;WANG He;SI Chunying;CAO Yingjie;XIE Jinhong(The First Clinical Medical College,Henan University of Chinese Medicine,Henan Province,Zhengzhou450000,China;Heart Center,the First Affiliated Hospital of Henan University of Chinese Medicine,Henan Province,Zhengzhou450000,China;Department of Pharmacy,the First Affiliated Hospital of Henan University of Chinese Medicine,Henan Province,Zhengzhou450000,China)

机构地区：[1]河南中医药大学第一临床医学院,河南郑州450000 [2]河南中医药大学第一附属医院心脏中心,河南郑州450000 [3]河南中医药大学第一附属医院药剂科,河南郑州450000

出　　处：《中国医药导报》2021年第34期43-46,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81473508、81603431)。

摘　　要：窦房结功能不全和心房颤动都是临床上常见的心律失常,二者经常共存并相互作用。心脏纤维化是一系列病理状况的标志,也是导致患者心脏功能障碍和预后不良的危险因素。目前许多研究表明纤维化与窦房结功能不全和心房颤动的发生发展密切相关,本文从纤维化在窦房结功能不全与心房颤动中的发病机制及其影响因素进行综述,从而了解窦房结疾病和心房颤动之间的复杂关系,为临床上治疗窦房结功能不全及心房颤动提供新的思路。Sinoatrial node dysfunction and atrial fibrillation are common arrhythmias in clinic,and they often coexist and interact with each other.Cardiac fibrosis is a marker of a series of pathological conditions and a risk factor leading to cardiac dysfunction and poor prognosis.At present,many studies have shown that fibrosis is closely related to the occurrence and development of sinoatrial node dysfunction and atrial fibrillation.This paper reviews the pathogenesis and influencing factors of fibrosis in sinoatrial node dysfunction and atrial fibrillation,to understand the complex relationship between sinoatrial node disease and atrial fibrillation,and to provide new ideas for clinical treatment of sinoatrial node dysfunction and atrial fibrillation.

关 键 词：窦房结功能不全 心房颤动 纤维化 

分 类 号：R541.7[医药卫生—心血管疾病]