益肾逐瘀汤联合醋酸亮丙瑞林微球治疗肾虚痰瘀型子宫内膜异位症的效果  

Effect of Yishen Zhuyu Decoction combined with Leuprolide Acetate Microspheres in the treatment of endometriosis with kidney deficiency and phlegm stasis

作　　者：陈静娴[1] 林海鹏 梁雪芳[3] 王永霞[3] 谭茜茜 CHEN Jingxian;LIN Haipeng;LIANG Xuefang;WANG Yongxia;TAN Xixi(Department of Obstetrics and Gynecology,Yangjiang Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Guangdong Province,Yangjiang529500,China;Ward Two,Department of Internal Medicine,People’s Hospital of Yangjiang Affiliated to Guangdong Medical University,Guangdong Province,Yangjiang529500,China;Department of Gynecology,Traditional Chinese Medicine Hospital of Guangdong Province,Guangdong Province,Guangzhou510000,China;Department of Medicine,People’s Hospital of Yangjiang Affiliated to Guangzhou Medical University,Guangdong Province,Yangjiang529500,China)

机构地区：[1]广州中医药大学附属阳江市中医医院妇产科,广东阳江529500 [2]广东医科大学附属阳江市人民医院内二科,广东阳江529500 [3]广东省中医院妇科,广东广州510000 [4]广东医科大学附属阳江市人民医院医务科,广东阳江529500

出　　处：《中国医药导报》2021年第35期93-96,109,共5页China Medical Herald

基　　金：广东省中医药局科研项目(20181118)。

摘　　要：目的分析益肾逐瘀汤联合醋酸亮丙瑞林微球治疗肾虚痰瘀型子宫内膜异位症(EMT)的临床效果。方法选取广州中医药大学附属阳江市中医医院2018年6月至2020年6月收治的80例EMT患者作为研究对象,依据随机数字表法分为两组,每组40例。对照组给予醋酸亮丙瑞林微球治疗;研究组在对照组基础上采用益肾逐瘀汤治疗。观察并记录两组患者临床疗效,治疗前后基质金属蛋白酶-9(MMP-9)、金属蛋白酶组织抑制因子-1(TIMP-1)水平以及不良反应发生情况。结果研究组临床疗效优于对照组(P<0.05)。治疗后,两组MMP-9水平低于治疗前,TIMP-1水平高于治疗前(P<0.05);研究组MMP-9水平低于对照组,TIMP-1水平高于对照组(P<0.05)。研究组不良反应总发生率低于对照组(P<0.05)。结论益肾逐瘀汤联合醋酸亮丙瑞林微球应用于EMT,有助于提高疗效,调节TIMP-1、MMP-9水平,减少不良反应的发生。Objective To analyze the clinical effect of Yishen Zhuyu Decoction combined with Leuprorelin Acetate Microspheres in the treatment of endometriosis(EMT)of kidney deficiency and phlegm stasis.Methods From June 2018 to June 2020,80 patients with EMT treated in Yangjiang Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine were selected as the research objects,according to random number table method,they were divided into two groups,with 40 cases in each group.The control group was treated with Leuprorelin Acetate Microspheres,and the study group was treated with Yishen Zhuyu Decoction on the basis of control group.The clinical efficacy,the levels of matrix metalloproteinase-9(MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1)before and after treatment and the occurrence of adverse reactions in two groups were observed and recorded.Results The clinical effect of study group was better than that of control group(P<0.05).After treatment,MMP-9 levels between two groups were lower than those before treatment,and TIMP-1 levels between two groups were higher than those before treatment(P<0.05);MMP-9 level in study group was lower than that in control group,and TIMP-1 level was higher than that in control group(P<0.05).The total incidence of adverse reactions in study group was lower than that in control group(P<0.05).Conclusion The application of Yishen Zhuyu Decoction combined with Leuprorelin Acetate Microspheres in EMT is helpful to improve the therapeutic effect,regulate the levels of TIMP-1 and MMP-9 and reduce adverse reactions.

关 键 词：子宫内膜异位症 益肾逐瘀汤 醋酸亮丙瑞林微球 基质金属蛋白酶-9 金属蛋白酶组织抑制因子-1 

分 类 号：R711.71[医药卫生—妇产科学]