针刺联合温脾通络开窍汤治疗痰浊阻窍型血管性痴呆的效果  

Effect of acupuncture combined with Wenpi Tongluo Kaiqiao Decoction in the treatment of vascular dementia with syndrome of phlegm turbidity obstructing the orifices

作　　者：国郑 师彬 王从安[2] 王洋 周佳惠 GUO Zheng;SHI Bin;WANG Cong’an;WANG Yang;ZHOU Jiahui(Department of Rehabilitation,Fuxin Mine General Hospital of Liaoning Health Industry Group,Liaoning Province,Fuxin123000,China;Department of Rehabilitation,Neck Shoulder Lumbar Leg Pain Hospital Affiliated to Shandong First Medical University,Shandong Province,Jinan250031,China;Department of Rrthopedics and Traumatology of Traditional Chinese Medicine,Shandong Medical Biotechnology Research Center,Shandong Province,Jinan250062,China)

机构地区：[1]辽宁省健康产业集团阜新矿总医院康复科,辽宁阜新123000 [2]山东第一医科大学附属颈肩腰腿痛医院康复科,山东济南250031 [3]山东省医药生物技术研究中心中医骨伤科,山东济南250062

出　　处：《中国医药导报》2021年第35期158-162,共5页China Medical Herald

基　　金：山东省自然科学基金项目(ZR2019MH134)。

摘　　要：目的探讨针刺联合温脾通络开窍汤治疗痰浊阻窍型血管性痴呆(VD)的效果。方法选取2018年1月至2021年3月辽宁省健康产业集团阜新矿总医院收治的113例痰浊阻窍型VD患者作为研究对象。采用随机数字表法将患者分为对照组(56例)和实验组(57例),对照组给予常规西医治疗联合针刺治疗,实验组在对照组的基础上给予温脾通络开窍汤治疗,两组均治疗12周。比较两组临床疗效、中医证候积分、简明精神状态(MMSE)量表、长谷川痴呆量表(HDS)、日常活动能力(ADL)量表、白细胞介素-6(IL-6)、血管内皮生长因子(VEGF)、肿瘤坏死因子-α(TNF-α),观察不良反应发生率。结果治疗后,实验组临床总有效率高于对照组(P<0.05)。治疗后,两组头痛如裹、智能减退、纳呆脘胀、沉默少言、动作迟缓、泛恶欲呕积分均降低,且实验组低于对照组(P<0.05)。治疗后,两组MMSE、HDS、ADL量表评分均升高,且实验组高于对照组(P<0.05)。治疗后,两组血清IL-6、TNF-α水平均降低,且实验组低于对照组(P<0.05),两组VEGF水平升高,且实验组高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论针刺联合温脾通络开窍汤治疗痰浊阻窍型VD患者,可迅速改善临床症状,疗效确切,可以降低炎症因子,改善生活能力、认知功能及神经功能。Objective To explore the effect of acupuncture combined with Wenpi Tongluo Kaiqiao Decoction in the treatment of vascular dementia(VD)with syndrome of phlegm turbidity obstructing the orifices.Methods A total of 113 VD patients with syndrome of phlegm turbidity obstructing the orifices admitted to Fuxin Mine General Hospital of Liaoning Health Industry Group from January 2018 to March 2021 were selected as the research subjects.According to the random number table method,the patients were divided into control group(56 cases)and experimental group(57 cases).The control group was treated with conventional Western medicine and acupuncture,and the experimental group was treated with Wenpi Tongluo Kaiqiao Decoction on the basis of the control group,both groups were treated for 12 weeks.The clinical efficacy,traditional Chinese medicine syndrome score,mini-mental state examination(MMSE)scale,Hasegawa dementia scale(HDS),activities of daily living(ADL)scale,interleukin-6(IL-6),vascular endothelial growth factor(VEGF),and tumor necrosis factor-α(TNF-α)in the two groups were compared,the incidence of adverse reactions were observed.Results After treatment,the total effective rate of the experimental group was higher than that in the control group(P<0.05).After treatment,the headache with binding sensation score,hypophrenia score,anorexia and abdominal distension score,silence score,slow movement score,and vomiting score in the two groups were decreased,which in the experimental group were lower than those in the control group(P<0.05).After treatment,the MMSE,HDS,and ADL scores in the two groups were increased,which in the experimental group were higher than those in the control group(P<0.05).After treatment,the levels of serum IL-6 and TNF-αin the two groups were decreased,and which in the experimental group were lower than those in the control group(P<0.05),the VEGF levels in the two groups were increased,which in the experimental group was higher than that in the control group(P<0.05).There was no significant differe

关 键 词：针刺 温脾通络开窍汤 血管性痴呆 临床疗效 

分 类 号：R246.6[医药卫生—针灸推拿学]