A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery  

作　　者：Yoo Na Kang Namsun Chou Jae-Won Jang Han Kyoung Choe Sohee Kim 

机构地区：[1]Department of Medical Assistant Robot,Korea Institute of Machinery&Materials(KIMM),Daegu,Republic of Korea [2]Center for BioMicrosystems,Korea Institute of Science and Technology(KIST),Seoul,Republic of Korea [3]Department of Robotics Engineering,Daegu Gyeongbuk Institute of Science and Technology(DGIST),Daegu,Republic of Korea [4]Department of Brain&Cognitive Sciences,Daegu Gyeongbuk Institute of Science and Technology(DGIST),Daegu,Republic of Korea

出　　处：《Microsystems & Nanoengineering》2021年第4期169-179,共11页微系统与纳米工程（英文）

基　　金：supported by the Brain Research Program under Grant No.NRF-2018M3C7A1022309 through the National Research Foundation of Korea.

摘　　要：The demand for multifunctional neural interfaces has grown due to the need to provide a better understanding of biological mechanisms related to neurological diseases and neural networks.Direct intracerebral drug injection using microfluidic neural interfaces is an effective way to deliver drugs to the brain,and it expands the utility of drugs by bypassing the blood-brain barrier(BBB).In addition,uses of implantable neural interfacing devices have been challenging due to inevitable acute and chronic tissue responses around the electrodes,pointing to a critical issue still to be overcome.Although neural interfaces comprised of a collection of microneedles in an array have been used for various applications,it has been challenging to integrate microfluidic channels with them due to their characteristic three-dimensional structures,which differ from two-dimensionally fabricated shank-type neural probes.Here we present a method to provide such three-dimensional needle-type arrays with chemical delivery functionality.We fabricated a microfluidic interconnection cable(pFIC)and integrated it with a flexible penetrating microelectrode array(FPMA)that has a 3-dimensional structure comprised of silicon microneedle electrodes supported by a flexible array base.We successfully demonstrated chemical delivery through the developed device by recording neural signals acutely from in vivo brains before and after KCl injection.This suggests the potential of the developed microfluidic neural interface to contribute to neuroscience research by providing simultaneous signal recording and chemical delivery capabilities.

关 键 词：NEURAL RECORDING NEEDLE 

分 类 号：R318[医药卫生—生物医学工程]