艾拉莫德片联合雷公藤多苷片在非绝经期类风湿关节炎女性患者中的安全性和有效性  

Safety and efficacy of iguratimod tablets combined with Leigongteng glucosides pills in non-menopausal female with rheumatoid arthritis

作　　者：吴影懿 费晶[1] 宋冬明 黄阳[1] WU Yingyi;FEI Jing;SONG Dongming;HUANG Yang(Department of Rheumatology and Immunology,Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu,214000)

机构地区：[1]江南大学附属医院风湿免疫科,江苏无锡214000

出　　处：《实用临床医药杂志》2021年第20期115-118,共4页Journal of Clinical Medicine in Practice

摘　　要：目的评估艾拉莫德片联合雷公藤多苷片在非绝经期类风湿关节炎(RA)女性患者中的安全性和有效性。方法选择首次接受药物治疗的非绝经期RA女性患者108例为研究对象,采用随机数字表法分为对照组和观察组,每组54例。对照组口服艾拉莫德片,观察组口服艾拉莫德片联合雷公藤多苷片;2组患者也可同时应用甲氨蝶呤或来氟米特治疗,疗程为3个月。比较2组患者治疗前后类风湿关节炎患者病情评价(DAS28)评分、类风湿因子(RF)、红细胞沉降率(ESR)、白细胞介素-1(IL-1)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和核转录因子(NF-κB)水平;评估2组临床疗效以及药物安全性。结果治疗后,2组DAS28评分、RF、ESR、IL-1、CRP、TNF-α和NF-κB水平均比治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。2组均未出现Ⅲ级药物毒性反应,内分泌和生殖系统也未出现明显不良反应。结论艾拉莫德片联合雷公藤多苷片治疗非绝经期RA女性患者有较好的安全性和有效性。Objective To evaluate safety and efficacy of iguratimod tablets combined with Leigongteng glucosides pills in non-menopausal female with rheumatoid arthritis(RA).Methods A total of 108 non-menopausal RA female patients who received drug therapy for the first time were randomly divided into control group and observation group by random number table method,with 54 cases in each group.The control group was given iguratimod tablets orally,and the observation group was given iguratimod tablets combined with Leigongteng glucosides pills orally.Patients in both groups were treated with methotrexate or leflunomide for 3 months.Disease Activity Score using 28 joint counts(DAS28)score,rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),interleukin-1(IL-1),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and nuclear transcription factor-κB(NF-κB)were compared between two groups before and after treatment.The clinical efficacy and drug safety of the two groups were evaluated.Results After treatment,DAS28 score,RF,ESR,IL-1,CRP,TNF-αand NF-κB levels in two groups were significantly lower than before treatment,and the observation group was significantly lower than the control group(P<0.05).The total effective rate for treatment in the observation group was significantly higher than that in the control group(P<0.05).There was no drug toxicity of gradeⅢin both groups,and no obvious adverse reactions occurred in endocrine and reproductive system.Conclusion Iguratimod tablets combined with Leigongteng glucosides pills has good safety and efficacy in the treatment of non-menopausal RA females.

关 键 词：类风湿关节炎 非绝经期 艾拉莫德片 雷公藤多苷片 

分 类 号：R593.22[医药卫生—内科学] R271.1[医药卫生—临床医学]