肾移植细胞毒交叉配型实验的临床分析及其意义  

The clinical analysis and significance of cytotoxin cross-matching test in kidney transplantation

作　　者：胡海亮[1] 李宁[1] 许伟[1] 刘淑均[1] 程越[1] 廖贵益[2] 卞茂红[1] 钟涛[1] Hu Hailiang;Li Ning;Xu Wei(Dept of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei 230022)

机构地区：[1]安徽医科大学第一附属医院输血科,合肥230022 [2]安徽医科大学第一附属医院泌尿外科,合肥230022

出　　处：《安徽医科大学学报》2021年第12期1995-1999,共5页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:1508085SMH226)。

摘　　要：目的总结分析微量淋巴毒交叉配型实验结果,探讨供受者基本情况分布及其临床意义。方法回顾性344例患者结果,分析供受者年龄、性别、血型分布以及供受者关系对微量淋巴细胞毒交叉配型实验结果的影响等。结果受者方面:受者中男性数量多于女性;受者年龄主要分布在21~50岁,其中低风险组中31~40岁受者死淋巴细胞百分比(PDL)最低(3.85±2.08);受者血型主要是A型和O型,供受者血型一致约占85.17%。供者方面:72.67%的供者是心脏死亡器官捐献(DCD),低风险组中DCD组受者PDL为(5.30±2.24),高于活体亲属捐献(LDR)组受者PDL,差异有统计学意义(P<0.05);在LDR组中,女性供者多于男性,年龄>50岁的供者最多,O型供者最多,93.02%的供者是父母亲。结论虽然DCD例数多于LDR,但是LDR受者PDL阳性率更低,且能够更快地提供肾源,有效解决肾衰竭患者的病痛。Objective To analyze the results of the micro lymphotoxin cross-matching test and explore the primary distribution of donors and recipients and its clinical significance.Methods 344 patients were analyzed,including age,gender,blood group distribution,donor-recipient relationship,and the influence was also investigated,respectively.Results In the aspect of recipients:the number of male recipients was more than that of female recipients,and the age of recipients was mainly between 21 and 50 years old.The PDL of 31~40 years receivers was the lowest in the low-risk group,which was(3.85±2.08);the recipients′blood types were mostly typed A and O,of which 85.17%of the donors and recipients had the same blood type.In the aspect of donors:72.67%of the donors were DCD;in the low-risk group,the PDL of the DCD group was(5.30±2.24),which was higher than that of LDR group,and the difference was statistically significant(P<0.05).In LDR,female donors were more than male donors,the donors over 50 years old were the most,type O donors were the most,and 93.02%of the donors were parents.Conclusion Although the number of DCD was more than that of LDR,the positive rate of PDL was lower in LDR,and it can provide kidney sources more quickly and effectively solve the pain of patients with renal failure.

关 键 词：肾移植 细胞毒交叉配型实验 亲属活体捐赠 公民逝世捐赠 性别 年龄 

分 类 号：R392.4[医药卫生—免疫学]