特发性膜性肾病足细胞的电镜观察分析  

Electron microscopic observation and analysis of podocytes in idiopathic membranous nephropathy

作　　者：付晓宇 邱明珠 刘庆宏[1] 李敏[1] 郑智勇[1] FU Xiao-yu;QIU Ming-zhu;LIU Qing-hong(Department of Pathology,the 900th Hospital of the Joint Logistics SupportForce,PLA,Fuzhou 350025,China;Department of Pathology,Longyan First Hospital Affiliated to Fujian Medical University)

机构地区：[1]中国人民解放军联勤保障部队第900医院病理科,福建福州350025 [2]福建医科大学附属龙岩第一医院病理科

出　　处：《中国实验诊断学》2021年第12期1771-1773,共3页Chinese Journal of Laboratory Diagnosis

基　　金：联勤保障部队第九〇〇医院科研计划(2017L12)。

摘　　要：目的观察特发性膜性肾病(IMN)中足细胞的超微结构改变,探讨IMN发病机制。方法对解放军联勤保障部队第900医院2014年6月至2017年9月已确诊并有完整临床资料的53例IMN进行回顾性病例对照研究,通过透射电镜(TEM)观察足细胞的形态学变化,探讨其发病机制。结果在TEM下,IMN的足细胞均有不同程度的足突融合/微绒毛变性、自噬溶酶体增多、线粒体肿胀、脂滴/蛋白滴及细胞膜破损。结论足细胞受损可作为区分特发性膜性肾病和继发性膜性肾病的一个诊断依据。Objective To observa the ultrastructural changes of podocytes in idiopathic membranous nephropathy(IMN)and explore the pathogenesis of IMN.Methods 53 cases of IMN with complete clinical data diagnosed in the900 th Hospital of the joint logistics support force of the PLA from June 2014 to September 2017 were studied by transmission electron microscope(TEM)to observe the morphological changes of podocytes and explore its pathogenesis.Results with the podocyte fusion/microvilli,mitochondrial swelling,vacuolar degeneration,lipid droplets/protein drop and cell membrane damage were obvious under TEM.Conclusion podocyte damage can be used as a diagnostic element to distinguish idiopathic membranous nephropathy from secondary membranous nephropathy.

关 键 词：膜性肾病 电镜 足细胞 

分 类 号：R692[医药卫生—泌尿科学]