OSAHS及其合并COPD患者血清促炎因子和抑炎因子水平变化分析  

Analysis on the Changes of Serum Pro-inflammatory Factors and Anti-inflammatory Factors in Patients with OSAHS and COPD

作　　者：郑梦凝[1,2] 张帮艳 吴丹 李玉彩[1,2] 王霄 张翊玲 万自芬 ZHENG Mengning;ZHANG Bangyan;WU Dan;LI Yucai;WANG Xiao;ZHANG Yiling;WAN Zifen(Department of Respiratory and Critical Care Medicine,Guizhou Provincial People's Hospital,Guiyang,Guizhou Province,550002 China;Key Laboratory of Diagnosis and Treatment of Pulmonary Immune Diseases,National Health Commission,Guiyang,Guizhou Province,550002 China)

机构地区：[1]贵州省人民医院呼吸与危重症医学科,贵州贵阳550002 [2]国家卫生健康委员会肺脏免疫性疾病诊治重点实验室,贵州贵阳550002

出　　处：《系统医学》2021年第22期14-17,共4页Systems Medicine

基　　金：贵州省基础研究计划(科学技术基金)(黔科合基础-ZK[2021]一般351)。

摘　　要：目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)及其合并慢性阻塞性肺疾病(COPD)患者血清促炎因子白细胞介素(IL)-18、IL-33及抑炎因子IL-10水平的变化,并探讨其临床意义。方法选取2017年8月—2018年12月就诊于该院的OSAHS患者57例,OSAHS合并COPD组(OS组)患者22例,随机选取健康体检者23名。采用酶联免疫吸附法(ELISA)检测血清IL-18、IL-33、IL-10水平,分析它们与疾病的相关性。结果OS组患者血清促炎因子IL-18(73.4±2.1)ng/L、IL-33(976.1±16.9)ng/L均显著高于OSAHS组IL-18(61.3±4.6)ng/L、IL-33(848.5±41.4)ng/L,OSAHS组高于对照组IL-18(52.2±2.0)ng/L、IL-33(760.4±20.0)ng/L。反之,OS组患者血清抑炎因子IL-10(126.0±4.6)ng/L水平较OSAHS组下降(156.1±11.4)ng/L,差异有统计学意义(P<0.01)。结论反复的夜间低氧血症可导致OSAHS组患者体内炎性因子水平升高,抑炎因子水平降低,炎症平衡失调,OS组患者由于反复缺氧及气道炎症加重炎症反应,可能是OSAHS合并COPD的重要机制。Objective To observe the changes of serum interleukin-18,IL-33 and IL-10 in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)and chronic obstructive pulmonary disease(COPD),and to explore their clinical significance.Methods A total of 57 OSAHS patients in the hospital from August 2017 to December 2018 were selected,22 patients in the OSAHS combined COPD group(OS group)were selected,and 23 healthy patients were randomly selected.Enzyme-linked immunosorbent assay(ELISA)was used to detect serum levels of IL-18,IL-33,and IL-10,and analyze their correlation with diseases.Results Serum pro-inflammatory factors IL-18(73.4±2.1)ng/L and IL-33(976.1±16.9)ng/L in OS group were significantly higher than IL-18(61.3±4.6)ng/L and IL-33(848.5±41.4)ng/L in OSAHS group.The OSAHS group was higher than IL-18(52.2±2.0)ng/L and IL-33(760.4±20.0)ng/L in the control group.On the contrary,the level of serum anti-inflammatory factor IL-10(126.0±4.6)ng/L in the OS group was lower than that in the OSAHS group(156.1±11.4)ng/L,the difference was statistically significant(P<0.01).Conclusion Repeated nocturnal hypoxemia can lead to increased levels of inflammatory factors in the OSAHS group,lower levels of anti-inflammatory factors,and inflammatory balance disorders.In the OS group,repeated hypoxia and airway inflammation aggravated the inflammatory response,which may be an important mechanism of OSAHS with COPD.

关 键 词：睡眠呼吸暂停 IL-18 IL-33 IL-10 慢性阻塞性肺疾病 

分 类 号：R56[医药卫生—呼吸系统]