氨磺必利和奥氮平在慢性精神分裂症合并糖尿病患者治疗中的效果分析  

Analysis of the Effect of Amisulpride and Olanzapine in the Treatment of Chronic Schizophrenia Patients with Diabetes

作　　者：屈胜男 王雷[2] QU Shengnan;WANG Lei(The Third Treatment Area of the Department of Psychiatry,the Sixth People's Hospital of Jilin,Jilin,Jilin Province,132000 China;Department of Nuclear Medicine,Jilin Provincial Tumor Hospital,Changchun,Jilin Province,130000 China)

机构地区：[1]吉林市第六人民医院精神科三疗区,吉林吉林132000 [2]吉林省肿瘤医院核医学科,吉林长春130000

出　　处：《系统医学》2021年第22期110-113,共4页Systems Medicine

基　　金：吉林省卫生与健康青年科技骨干培养计划项目(2020Q037)。

摘　　要：目的探索分析氨磺必利和奥氮平在慢性精神分裂症合并糖尿病患者治疗中的效果。方法选取吉林市第六人民医院2018年3月—2019年9月收治的76例慢性精神分裂症合并糖尿病患者,并随机分成研究组和对照组,各38例。其中对照组患者给予奥氮平药物口服治疗,同时进行降糖治疗,研究组患者给予氨磺必利药物治疗,同时进行降糖治疗与饮食指导,治疗10周之后对两组的治疗效果进行综合分析,对比两组的总有效率、血糖情况。结果治疗后研究组空腹血糖(6.03±1.02)mmol/L,对照组空腹血糖(7.59±1.86)mmol/L,差异有统计学意义(t=4.533,P<0.001);治疗后研究组餐后2 h血糖(7.11±0.58)mmol/L,对照组餐后2 h血糖(8.26±1.52)mmol/L,差异有统计学意义(t=4.357,P<0.001);治疗组患者的治疗有效率为86.84%,与对照组的治疗有效率65.79%相比明显较高,差异有统计学意义(χ^(2)=4.659,P<0.05)。结论慢性精神分裂症合并糖尿病患者利用氨磺必利所起的治疗效果明显好于奥氮平,值得临床推广。Objective To explore and analyze the effects of amisulpride and olanzapine in the treatment of patients with chronic schizophrenia and diabetes.Methods A total of 76 patients with chronic schizophrenia and diabetes mellitus admitted to the Sixth People's Hospital of Jilin City from March 2018 to September 2019 were selected and randomly divided into a study group and a control group,with 38 cases in each.Patients in the control group were given olanzapine orally and hypoglycemic therapy at the same time.Patients in the study group were given amisulpride drug treatment,along with hypoglycemic therapy and dietary guidance.After ten weeks of treatment,the treatment effects of the two groups were comprehensively analyzed,and the total effective rate of the two groups and blood glucose situation were compared.Results After treatment,the fasting blood glucose of the study group was(6.03±1.02)mmol/L,and the fasting blood glucose of the control group was(7.59±1.86)mmol/L,the difference was statistically significant(t=4.533,P<0.001);after treatment,the blood glucose of the study group was(7.11±0.58)mmol/L two hours after the meal,and the blood glucose of the control group was(8.26±1.52)mmol/L 2 h after the meal,the difference was statistically significant(t=4.357,P<0.001);the effective rate of treatment in the study group was 86.84%,which was significantly higher than the control group,the treatment effect rate 65.79%,and the difference was statistically significant(χ^(2)=4.659,P<0.05).Conclusion Patients with chronic schizophrenia and diabetes mellitus with amisulpride have significantly better therapeutic effects than olanzapine,which is worthy of clinical promotion.

关 键 词：氨磺必利 奥氮平 慢性精神分裂症 糖尿病 效果评价 临床疗效 

分 类 号：R4[医药卫生—临床医学]