甘精胰岛素联用阿卡波糖治疗老年糖尿病有效性  

Effectiveness of Insulin Glargine Combined with Acarbose in the Treatment of Senile Diabetes

作　　者：李平[1] LI Ping(Zibo City Center for Disease Control and Prevention,Zibo,Shandong Province,255000 China)

机构地区：[1]山东省淄博市疾病预防控制中心,山东淄博255000

出　　处：《糖尿病新世界》2021年第23期94-97,共4页Diabetes New World Magazine

摘　　要：目的评价甘精胰岛素联用阿卡波糖用于老年糖尿病的治疗效果。方法选取2020年6月—2021年6月期间该院收治的老年糖尿病患者124例作为研究对象,用随机数表法的原则将其分为两组,每组62例。对照组采用甘精胰岛素治疗,观察组采用甘精胰岛素联用阿卡波糖治疗,评价比较两种治疗方案对治疗有效性和安全性的影响。结果观察组临床总有效率高于对照组,差异有统计学意义(P<0.05);治疗后两组的血糖值和治疗前相比均明显降低,而观察组治疗后患者的各项血糖值低于对照组,差异有统计学意义(P<0.05);观察组患者的血糖达标时间短于对照组,胰岛素用量少于对照组,差异有统计学意义(P<0.05);观察组治疗后患者的空腹胰岛素和餐后2 h胰岛素水平均显著高于对照组,差异有统计学意义(P<0.05);经评估两种用药方案的安全性,结果提示治疗期间两组患者均出现了一些胃肠道不良反应和低血糖症状,但观察组和对照组的不良反应发生率相比差异无统计学意义(P>0.05)。结论老年糖尿病患者接受甘精胰岛素联用阿卡波糖治疗兼具有效性和安全性,既有利于平稳降糖,又可以缩短患者的血糖达标时间,减少胰岛素的使用剂量,故此种治疗方案具备临床借鉴意义和推广的价值。Objective To evaluate the effect of insulin glargine combined with acarbose in the treatment of senile diabetes.Methods A total of 124 elderly diabetic patients from June 2020 to June 2021 admitted to the hospital were selected as the main subjects. They were divided into two groups by the principle of random number table method, with 62 cases in each group. The control group was treated with insulin glargine, and the observation group was treated with insulin glargine combined with acarbose. To evaluate and compare the effects of two treatment options on the effectiveness and safety of treatment. Results The total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P <0.05);the blood glucose values of the two groups after treatment were significantly lower than those before treatment, while the blood glucose values of the patients in the observation group were lower after treatment in the control group, the difference was statistically significant(P<0.05);the observation group had shorter blood glucose reaching standard time than the control group, and insulin consumption was less than the control group, the difference was statistically significant(P <0.05);the fasting insulin and 2 h postprandial insulin levels of the patients after a meal in observation group were significantly higher than those of the control group, and the difference was statistically significant(P<0.05);after evaluating the safety of the two medication regimens, the results indicated that both groups of patients had symptoms during the treatment period. Some gastrointestinal adverse reactions and symptoms of hypoglycemia, but there was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group(P >0.05). Conclusion The treatment of elderly diabetic patients with insulin glargine combined with acarbose is both effective and safe. It is not only conducive to smooth hypoglycemia, but als

关 键 词：甘精胰岛素 阿卡波糖 老年糖尿病 血糖值 有效性 安全性 

分 类 号：R587.1[医药卫生—内分泌]