2型糖尿病对慢性牙周炎患者血细胞及凝血机制的影响  

Effect of Type 2 Diabetes on Blood Cells and Coagulation Mechanism in Patients with Chronic Periodontitis

作　　者：郭楠[1] 林耿冰[1] GUO Nan;LIN Gengbing(Department of Stomatology,the Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian Province,350000 China)

机构地区：[1]福建中医药大学附属人民医院口腔科,福建福州350000

出　　处：《糖尿病新世界》2021年第22期12-14,18,共4页Diabetes New World Magazine

基　　金：国家中医临床研究基地专项科研课题(JDZX201903)。

摘　　要：目的探讨2型糖尿病对慢性牙周炎患者血细胞及凝血机制的影响。方法选取2020年8月—2021年7月该院口腔科收治2型糖尿病合并慢性牙周炎患者102例作为观察组,选择同期在该院治疗的慢性牙周炎患者102例作为对照组,比较两组患者的血细胞和凝血机制情况。结果观察组患者PLT、WBC及MPV水平较对照组增高,RBC、PDW水平较对照组降低,差异有统计学意义(P<0.05)。观察组患者vWF、TT和FIB水平较对照组降低,PT、APTT较对照组高,差异有统计学意义(P<0.05)。两组患者血糖水平与RBC呈显著相关;对照组患者的血糖与PLT、WBC、PDW、MPV、PT、APTT呈显著性相关,与vWF、TT和FIB呈高度相关;观察组患者的血糖与PLT、WBC、PDW、MPV、PT、APTT呈高度相关,v WF、TT和FIB呈显著性相关。2型糖尿病伴慢性牙周炎患者血糖与RBC、PLT、WBC、PDW、MPV相关程度高于2型糖尿病患者,但2型糖尿病伴慢性牙周炎患者血糖与vWF、PT、APTT、TT和FIB相关程度低于2型糖尿病患者。结论 2型糖尿病对慢性牙周炎患者的血细胞和凝血机制均有影响,临床可根据血常规和凝血指标进行诊断和针对性治疗。Objective To investigate the effect of type 2 diabetes on blood cells and coagulation mechanism in patients with chronic periodontitis. Methods From August 2020 to July 2021, 102 patients with type 2 diabetes and chronic periodontitis admitted to the Department of Stomatology of the hospital were selected as the observation group, and 102 patients with chronic periodontitis treated in the hospital in the same period were selected as the control group. The blood cells and coagulation mechanism of the two groups of patients were compared. Results The levels of PLT, WBC and MPV in the observation group were higher than those in the control group, and the level of RBC, PDW were lower than that in the control group, and the difference was statistically significant(P<0.05). The levels of vWF, TT and Fib in the observation group were significantly lower than those in the control group, PT, APTT were higher than those in the control group, and the difference was statistically significant(P<0.05). The blood glucose levels of the two groups were significantly correlated with RBC;the blood glucose in the control group was significantly correlated with PLT, WBC, PDW, MPV, PT and APTT, and was highly correlated with vWF, TT and FIB. The blood glucose of the observation group was highly correlated with PLT, WBC, PDW, MPV, PT and APTT, and vWF, TT and FIB were significantly correlated. The correlation between blood glucose and RBC, PLT, WBC, PDW and MPV in patients with type 2 diabetes mellitus and chronic periodontitis was higher than that in patients with type 2 diabetes mellitus, but the correlation between blood glucose and vWF, PT, APTT, TT and FIB in patients with type 2 diabetes mellitus and chronic periodontitis was lower than that in patients with type 2 diabetes mellitus. Conclusion Type 2 diabetes has an impact on the blood cells andcoagulation mechanism of patients with chronic periodontitis.Clinical diagnosis and targeted treatment can be performed based on blood routines and coagulation indicators.

关 键 词：2型糖尿病 慢性牙周炎 凝血机制 血细胞 

分 类 号：R587.1[医药卫生—内分泌]