甘精胰岛素联合门冬胰岛素对糖尿病合并白内障患者超声乳化术后血糖与眼表的影响  

Effects of Insulin Glargine Combined with Insulin Aspart on Blood Glucose and Ocular Surface after Phacoemulsification in Diabetic Patients with Cataract

作　　者：陈焓[1] CHEN Han(The First Affiliated Hospital of Xiamen University,Xiamen,Fujian Province,361003 China)

机构地区：[1]厦门大学附属第一医院,福建厦门361003

出　　处：《糖尿病新世界》2021年第22期61-64,共4页Diabetes New World Magazine

摘　　要：目的对行超声乳化手术糖尿病合并白内障患者应用甘精胰岛素联合门冬胰岛素的临床效果进行探讨,分析不同调控血糖方式对患者血糖和眼表的影响。方法将2019年2月—2020年2月期间前来该院治疗的100例糖尿病合并白内障患者列为研究对象,所有患者均行超声乳化术,根据随机抽样法把患者随机分成常规组(50例)和研究组(50例)。常规组患者使用门冬胰岛素注射液治疗,研究组使用门冬胰岛素注射液联合甘精胰岛素注射液对患者施以治疗,观察患者治疗效果(血糖水平、眼表疾病指数、切口和上皮修复时间、泪液和泪膜以及角膜情况)。结果研究组术后1周的眼表疾病指数为(24.55±2.22)分,明显少于常规组,差异有统计学意义(t=8.068,P<0.05);研究组术后1个月泪液分泌量(11.88±1.69)mm多于常规组,差异有统计学意义(t=9.185,P<0.05);泪膜破裂时间(11.88±1.55)s多于常规组,差异有统计学意义(t=11.012,P<0.05);研究组空腹血糖、餐后2 h血糖水平依次为(5.87±0.55)、(7.50±0.67)mmol/L,明显优于常规组,差异有统计学意义(t=14.636、9.562,P<0.05)。结论为糖尿病合并白内障患者使用角巩膜缘切口超声乳化术进行治疗前,选择甘精胰岛素注射液联合门冬胰岛素注射液方式对其血糖水平进行干预,能够降低患者血糖指标,促进患者康复。Objective To investigate the clinical effects of insulin glargine combined with insulin aspart in patients with diabetes and cataract undergoing phacoemulsification, and to analyze the effects of different blood glucose control methods on patients’ blood glucose and ocular surface. Methods 100 patients with diabetes and cataract who came to the hospital for treatment from February 2019 to February 2020 were included as study subjects. All patients underwent phacoemulsification,and the patients were randomly divided into a routine group(50 cases) and a study group(50 cases) according to the random sampling method. Patients in the routine group were treated with insulin aspart injection, and the study group was treated with insulin aspart injection combined with insulin glargine injection. Observed the patient’s treatment effect(blood glucose level, ocular surface disease index, incision and epithelial repair time, tears and tear film, and corneal conditions). Results The ocular surface disease index of the study group at 1 week after operation was(24.55±2.22)points, which was significantly lower than that of the routine group, the difference was statistically significant(t=8.068, P<0.05). The amount of tear secretion in the study group was(11.88±1.69)mm more than that in the routine group at 1 month after surgery, the difference was statistically significant(t=9.185, P<0.05). The tear film rupture time(11.88±1.55)s was longer than that of the routine group, the difference was statistically significant(t=11.012, P<0.05). The fasting blood glucose and the 2 hours postprandial blood glucose levels of the study group were(5.87±0.55)mmol/L and(7.50±0.67)mmol/L, significantly better than the routine group, the difference was statistically significant(t =14.636,9.562, P <0.05). Conclusion Before using limbal corneoscleral incision phacoemulsification for diabetic patients with cataract, choose insulin glargine injection combined with insulin aspart injection to intervene their blood glucose level, which can redu

关 键 词：甘精胰岛素 门冬胰岛素 超声乳化术 糖尿病合并白内障 血糖 眼表 

分 类 号：R59[医药卫生—内科学]