速效胰岛素类似物诺和锐对初诊妊娠糖尿病治疗的临床评价  

Clinical Evaluation of Rapid-acting Insulin Analogue NowRapid Penfill for the Treatment of Newly Diagnosed Gestational Diabetes

作　　者：石小凤[1] 聂自良[1] SHI Xiaofeng;NIE Ziliang(Department of Obstetrics and Gynecology,Hong'an County People's Hospital,Hong'an,Hubei Province,438400 China)

机构地区：[1]红安县人民医院妇产科,湖北红安438400

出　　处：《糖尿病新世界》2021年第22期88-90,94,共4页Diabetes New World Magazine

摘　　要：目的观察速效胰岛素类似物诺和锐对初诊妊娠糖尿病(GDM)患者的临床疗效。方法选择2020年1—12月接诊的68例初诊GDM患者,随机分为观察组(34例,行速效胰岛素类似物诺和锐治疗)、对照组(34例,行生物合成人胰岛素治疗),评价组间胰岛素功能、血糖相关指标、并发症发生率、新生儿指标、不良妊娠结局。结果 (1)治疗前,组间胰岛素功能[胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)、C肽]、血糖相关指标[空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 hPG)]差异无统计学意义(P>0.05);治疗后,观察组HOMA-IR、HOMA-β、C肽、FPG、HbA1c、2 hPG优于对照组,差异有统计学意义(P<0.05)。(2)在并发症发生率方面,观察组(2.94%)低于对照组(17.65%),差异有统计学意义(P<0.05)。(3)组间新生儿畸形发生率差异无统计学意义(P>0.05),观察组巨大儿(2.94%)、呼吸窘迫(5.88%)、早产儿(2.94%)发生率低于对照组(17.65%、26.47%、20.59%),差异有统计学意义(P<0.05)。(4)观察组羊水过多(0.00%)、妊娠期高血压(2.94%)、剖宫产(11.76%)发生率低于对照组(14.71%、17.65%、35.29%),差异有统计学意义(P<0.05)。结论对初诊GDM患者行速效胰岛素类似物诺和锐治疗,可以改善胰岛素功能,增强血糖控制效果,减少并发症及不良母婴妊娠结局,值得推广。Objective To observe the clinical efficacy of fast-acting insulin analogue NowRapid Penfill on newly diagnosed gestational diabetes(GDM) patients. Methods A total of 68 newly diagnosed GDM patients who were admitted from January to December 2020 were selected and randomly divided into observation group(34 cases were treated with rapid-acting insulin analogue NowRapid Penfill) and control group(34 cases, undertaking biosynthetic human insulin therapy) to evaluate insulin function, blood glucose-related indicators, complication rates, neonatal indicators, and adverse pregnancy outcomes between groups. Results 1.Before treatment, insulin function between groups [insulin resistance index(HOMA-IR),islet β cell function index(HOMA-β), C peptide], blood glucose related indexes [fasting plasma glucose(FPG), glycosylated hemoglobin(HbA1 c) and 2 h postprandial plasma glucose(2 hPG)] had no statisticallysignificant difference(P>0.05);after treatment, HOMA-IR, HOMA-β, C-peptide, FPG, HbA1 c, 2 hPG in the observation group were better than the control group, the difference was statistically significant(P<0.05). 2.In terms of the incidence of complications, the observation group(2.94%) was lower than the control group(17.65%), the difference was statistically significant(P<0.05). 3.there was no statistically significant difference in the incidence of neonatal abnormalities between the groups(P>0.05), the observation group was huge(2.94%), respiratory distress(5.88%), premature infants(2.94%) were lower than the control group(17.65%,26.47%, 20.59%), the difference was statistically significant(P<0.05).4.the observation group had polyhydramnios(0.00%), the incidence of hypertension during pregnancy(2.94%), and cesarean section(11.76%) were lower than those of the control group(14.71%, 17.65%, 35.29%), the difference was statistically significant(P<0.05). Conclusion The rapid-acting insulin analog NowRapid Penfill treatment for newly diagnosed GDM patients can improve insulin function, enhance the effect of blood glucose cont

关 键 词：速效胰岛素类似物 诺和锐 初诊 妊娠糖尿病 治疗效果 

分 类 号：R714.256[医药卫生—妇产科学]