小剂量胰岛素持续滴注对小儿糖尿病酮症酸中毒临床疗效与安全性的影响  

Effect of Continuous Instillation of Low-dose Insulin on Clinical Efficacy and Safety of Children with Diabetic Ketoacidosis

作　　者：邱红珠 QIU Hongzhu(The Second Hospital of Sanming City,Sanming,Fujian Province,366000 China)

机构地区：[1]三明市第二医院,福建三明366000

出　　处：《糖尿病新世界》2021年第22期191-194,共4页Diabetes New World Magazine

摘　　要：目的研讨小儿糖尿病酮症酸中毒应用小剂量胰岛素持续滴注方式的临床效果,并分析其安全性。方法选取2017年1月—2020年12月于该院进行诊治的糖尿病酮症酸中毒患儿(30例),利用随机奇偶数分组法将患儿分为参照组与观察组,每组15例,参照组以常规方式对患儿施以治疗,观察组应用小剂量胰岛素持续滴注对患儿施以治疗,分析并对比两组患儿临床治疗效果。结果观察组患儿并发症发生率为6.6%,空腹血糖、餐后2 h血糖、血糖降低速度、白介素-6指标分别为(6.12±1.34)mmol/L、(7.79±1.14)mmol/L、(5.56±0.64)mmol/(L·h)、(25.06±3.61)pg/m L,其数据显著优于参照组,差异有统计学意义(P<0.05)。结论小剂量胰岛素持续滴注治疗小儿糖尿病酮症酸中毒可以提高临床疗效,降低并发症发生率,改善患者血糖水平、炎症因子水平,值得在临床中大力推荐。Objective To study the clinical effect of continuous infusion of low-dose insulin in children with diabetic ketoacidosis and analyze its safety. Methods A total of 30 children with diabetic ketoacidosis who were diagnosed and treated in the hospital from January 2017 to December 2020 were selected. The children were divided into a reference group and an observation group by random odd-even number grouping method, each group were 15 cases. The reference group was treated in a conventional way, and the observation group was treated with low-dose insulin continuous infusion. The clinical treatment effects of the two groups were analyzed and compared. Results The incidence of complications in the observation group was 6.6%. Fasting blood glucose, 2 h postprandial blood glucose, blood glucose lowering rate, and interleukin-6 indexes were(6.12±1.34)mmol/L,(7.79±1.14)mmol/L,(5.56±0.64)mmol/(L·h),(25.06±3.61) pg/m L, the data was significantly better than the reference group, the difference was statistically significant(P <0.05). Conclusion Continuous infusion of low-dose insulin in the treatment of children with diabetic ketoacidosis can improve the clinical efficacy, reduce the incidence of complications, and improve the blood glucose level and inflammatory factor levels of patients. It is worthy of clinical recommendation.

关 键 词：小儿糖尿病酮症酸中毒 胰岛素 小剂量持续滴注 血糖水平 炎症因子 安全性 

分 类 号：R59[医药卫生—内科学]