训练免疫在相关疾病中的研究进展  

Research on trained immunity in related disease

作　　者：苏可 王经琳 任昊桢[1] 施晓雷[1] SU Ke;WANG Jinglin;REN Haozhen;SHI Xiaolei(Department of Hepatobiliary Surgery,the Affiliated Drum Tower Hospital of Medical School of Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院肝胆外科,江苏南京210008

出　　处：《南京医科大学学报（自然科学版）》2021年第11期1695-1701,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81872359)。

摘　　要：训练免疫(trained immunity,TI)是不依赖T、B细胞的,区别于传统固有免疫特征的一种记忆性固有免疫应答,在机体初次感染后对相同或不同病原体再次感染表现高反应性。训练免疫作为一种新兴的观点,具体机制涉及固有免疫、代谢及表观遗传之间的交互作用。基于此,本文总结了脂多糖(lipopolysaccharide,LPS)、卡介苗(bacille calmette-guerin,BCG)、激素等刺激对单核/巨噬细胞、自然杀伤细胞等先天免疫细胞以及非经典免疫细胞的表观遗传和代谢修饰的影响,并探讨了调节训练免疫在炎症、神经系统疾病以及新冠肺炎等方面的作用。Trained immunity(TI),independent of the T and B cells and distinct from the characteristic of traditional innate immune,is a memorial innate immune response.The organism can show increased responsiveness upon subsequent stimulation with the same or a different stimulus,well after the initial challenge.Trained immunity,as a new concept,involves the interaction of innate immune and the metabolic and epigenetic mechanisms.Based on this,this article summarized the effects of stimulation such as lipopolysaccharide(LPS),bacille calmette-guerin(BCG),and hormones on epigenetic and metabolic modifications of innate immune cells such as monocytes/macrophages,natural killer cells and non-classical immune cells,and explored the long-term vision of modulating training immunity in inflammation,nervous system diseases and COVID-19.

关 键 词：训练免疫 固有免疫 免疫记忆 代谢重组 表观遗传重编程 

分 类 号：R329.12[医药卫生—人体解剖和组织胚胎学]