可乐定透皮贴片和盐酸硫必利治疗慢性抽动障碍的疗效  

Efficacy of Clonidine Transdermal Patch and Tiapride Hydrochloride in the Treatment of Chronic Tic Disorder

作　　者：顾水琴 GU Shuiqin(Department of Pediatrics,Changshu Hospital of Traditional Chinese Medicine,Changshu,Jiangsu Province,215500 China)

机构地区：[1]常熟市中医院儿科,江苏常熟215500

出　　处：《系统医学》2021年第23期117-120,共4页Systems Medicine

摘　　要：目的探究慢性抽动障碍患儿应用可乐定透皮贴片和盐酸硫必利治疗的成效。方法选择该院2018年12月—2020年12月接诊的慢性抽动障碍患儿70例,根据随机数表法分为两组,命名为对照组(35例)与观察组(35例)。给予对照组盐酸硫必利治疗,给予观察组在对照组治疗之上+可乐定透皮贴片治疗,将两组慢性抽动障碍患儿的治疗效果进行比较。结果观察组治疗2、4、6、8周的总有效率(85.71%、91.43%、94.29%、97.14%)高于对照组(60.00%、68.57%、77.14%、77.14%),差异有统计学意义(χ^(2)=5.851、5.714、4.200、4.590,P<0.05)。观察组治疗2、4、6、8周的YGTSS总减分率(35.73±5.21)%、(52.28±4.24)%、(59.23±4.32)%、(63.46±5.77)%优于对照组(18.88±5.31)%、(36.25±4.22)%、(48.39±5.05)、(56.98±6.28)%,差异有统计学意义(t=13.400、15.852、9.649、4.495,P<0.001)。观察组不良反应(皮肤瘙痒、脱贴、皮肤发红、口干、恶心、头晕、困倦)率小于对照组(5.71%vs 37.14%),差异有统计学意义(χ^(2)=10.266,P=0.001)。结论慢性抽动障碍患儿应用可乐定透皮贴片和盐酸硫必利治疗疗效更佳,且可乐定透皮贴片可以更好地降低患者的不良反应,安全性较高,值得在临床中进行使用和推广。Objective To explore the effect of clonidine transdermal patch and tiapride hydrochloride treatment in children with chronic tic disorder.Methods Selected 70 patients with chronic tic disorder admitted in the hospital from December 2018 to December 2020,and divided them into 2 groups according to the random number table method,named the control group(35 children)and the observation group(35 children).The control group was given tiapride hydrochloride treatment,and the observation group was given the treatment above the control group+clonidine transdermal patch treatment.The treatment effects of the two groups of children with chronic tic disorder were compared.Results The total effective rate(85.71%,91.43%,94.29%,97.14%)of the observation group for 2 weeks,4 weeks,6 weeks,and 8 weeks was higher than that of the control group(60.00%,68.57%,77.14%,77.14%),the difference was statistically significant(χ^(2)=5.851,5.714,4.200,4.590,P<0.05).The total reduction rate of YGTSS in the observation group for 2 weeks,4 weeks,6 weeks,and 8 weeks was(35.73±5.21)%,(52.28±4.24)%,(59.23±4.32)%,(63.46±5.77)% better than the control group(18.88±5.31)%,(36.25±4.22)%,(48.39±5.05)%,(56.98±6.28)%,the difference was statistically significant(t=13.400,15.852,9.649,4.495,P<0.001).The rate of adverse reactions(skin itching,peeling off,skin redness,dry mouth,nausea,dizziness,drowsiness)in the observation group was lower than that in the control group(5.71%vs 37.14%),the difference was statistically significant(χ^(2)=10.266,P=0.001).Conclusion Clonidine transdermal patch and tiapride hydrochloride have better therapeutic effects for patients with chronic tic disorders,and clonidine transdermal patch can better reduce the adverse reactions of children,with high safety,which is worthy of clinical use and promotion.

关 键 词：可乐定透皮贴片 盐酸硫必利 慢性抽动障碍 YGTSS评分 不良反应 

分 类 号：R72[医药卫生—儿科]