丹参单体化合物及丹参类制剂对心脑血管系统信号通路影响的研究进展  

Research progress on signaling pathway effect of cardiovascular and cerebrovascular system of Salvia miltiorrhiza monomer and its preparationson

作　　者：陈璐 聂永伟 张燕欣 万梅绪[3,4] 李智 李德坤 鞠爱春[3,4] CHEN Lu;NIE Yongwei;ZHANG Yanxin;WAN Meixu;LI Zhi;LI Dekun;JU Aichun(Hebei University of Traditional Chinese Medicine,Shijiazhuang 050200,China;School of Medicine,Nankai University,Tianjin 300071,China;Tianjin Tasly Pride Pharmaceutical Co.,Ltd.,Tianjin 300410,China;Tianjin Key Laboratory of Safety Evaluation Enterprise of Traditional Chinese Medicine Injections,Tianjin 300410,China)

机构地区：[1]河北中医学院,河北石家庄050200 [2]南开大学医学院,天津300071 [3]天津天士力之骄药业有限公司,天津300410 [4]天津市中药注射剂安全性评价企业重点实验室,天津300410

出　　处：《药物评价研究》2021年第11期2333-2342,共10页Drug Evaluation Research

摘　　要：丹参Salvia miltiorrhiza因具有活血化瘀的功效在临床上被广泛使用,以其有效成分制成的丹参类制剂的应用范围也不断扩大。近年来围绕注射用丹参多酚酸、注射用丹参多酚酸盐、丹红注射液、丹参注射液等丹参类制剂及其单体成分(如丹酚酸A、丹酚酸B、丹参素、迷迭香酸等)在治疗心脑血管系统方面开展了大量药理机制的研究,表明其可以通过调控核因子-κB(NF-κB)、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)、丝裂原活化蛋白激酶(MAPK)、Janus酪氨酸蛋白激酶(JAK)/信号转导及转录激活因子(STAT)等多种信号通路,发挥抗炎、抗氧化、抑制凋亡等药理作用。归纳总结丹参中的单体化合物及丹参类制剂对心脑血管系统相关信号通路的药理作用,以期为注射用丹参多酚酸药理作用分子机制的研究提供依据。Salvia miltiorrhiza is widely used in clinic because of its effect of promoting blood circulation and removing blood stasis.The application range of modern Salvia miltiorrhiza preparations made from its active ingredients is also expanding.In recent years,a large number of pharmacological mechanisms have been studied on Salvianolic Acid for Injection,Salvianolate for Injection,Danhong Injection,Danshen Injection and other salvianolic acid preparations,as well as their monomeric components,such as salvianolic acid A,salvianolic acid B,danshensu and rosinic acid in the treatment of cardiovascular and cerebrovascular systems.,and it has been shown that it has passed the preliminary exploration of nuclear factor-κB(NF-κB)and phosphatidylinositol 3-Kinase(PI3K)/protein kinase B(Akt),mitogen-activated protein kinase(MAPK),Janus tyrosine protein kinase(JAK)/signal transducer and activator of transcription(STAT)and other signaling pathway anti-inflammatory,anti-oxidant,inhibit apoptosis and other effects.This study summarized the relevant signal pathways by consulting relevant literature,hoping to provide ideas for future research on the molecular mechanism of Salvianolic Acid for Injection.

关 键 词：注射用丹参多酚酸 注射用丹参多酚酸盐 丹红注射液 丹酚酸A 丹酚酸B 心脑血管系统 信号通路 

分 类 号：R285.5[医药卫生—中药学]