5种丹参类注射剂临床配伍禁忌文献研究  

Literature study on clinical incompatibility of five kinds of Salvia miltiorrhiza injection

作　　者：宋美珍[1,2] 侯颖 吕欣 王蕴华 张彦明[1,2] 苏智刚 李德坤 SONG Meizhen;HOU Ying;LÜ Xin;WANG Yunhua;ZHANG Yanming;SU Zhigang;LI Dekun(Tianjin Tasly Pride Pharmaceutical Co.,Ltd.,Tianjin 300410,China;Tianjin Key Laboratory of Safety Evaluation Enterprise of Traditional Chinese Medicine Injections,Tianjin 300410,China;Tianjin Tasly Pharmaceutical Commercial Co.,Ltd.,Tianjin 300410,China)

机构地区：[1]天津天士力之骄药业有限公司,天津300410 [2]天津市中药注射剂安全性评价企业重点实验室,天津300410 [3]天津天士力医药商业有限公司,天津300410

出　　处：《药物评价研究》2021年第11期2343-2349,共7页Drug Evaluation Research

摘　　要：含有丹参Salvia miltiorrhiza的中药注射剂主要包括丹参注射液、丹参滴注液、注射用丹参(冻干)、注射用丹参多酚酸盐和注射用丹参多酚酸。其在临床应用中存在配伍禁忌,如配伍后发生理化性质的变化,与抗癌药物进行配伍后会促进恶性肿瘤的转移,与止血药、雄激素、阿托品等药物配伍会降低丹参类注射剂的疗效,与抗凝药配伍会导致出血现象的发生等。对5种丹参类注射剂配伍禁忌的相关文献进行归类总结,以期为该类注射剂在临床中的合理应用提供指导。Traditional Chinese medicine injections containing Salvia miltiorrhiza mainly including Salvia miltiorrhiza Injection,Salvia miltiorrhiza Infusion Solution,Salvia miltiorrhiza Injection(freeze-dried),Salvia miltiorrhiza Polyphenol Acid for Injection and Salvianolic Acids for Injection.There are many incompatibility contraindications in clinical application,such as:physical and chemical properties change after incompatibility,incompatibility with anticancer drugs will promote the metastasis of malignant tumors;compatibility with hemostatic,androgen,atropine and other drugs can reduce the efficacy of Salvia miltiorrhiza preparation;compatibility with anticoagulants can cause bleeding.Relevant literatures on the incompatibility of five Salvia miltiorrhiza preparations are classified and summarized in order to provide guidance for the clinical application of these preparations.

关 键 词：丹参 丹参注射液 丹参滴注液 注射用丹参(冻干) 注射用丹参多酚酸盐 注射用丹参多酚酸 配伍禁忌 

分 类 号：R942[医药卫生—药剂学]