血浆Lp-PLA_(2)水平评估冠心病患者病情及冠状动脉病变的价值  

Value of Plasma Lp-PLA_(2) level in the Evaluation of Disease Condition and Coronary Artery Lesions of Patients with Coronary Artery Disease

作　　者：王洪恩 周瑞红 杨文忠 WANG Hongen;ZHOU Ruihong;YANG Wenzhong(Department of Cardiology,Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Suzhou 215101,China)

机构地区：[1]苏州市中西医结合医院心内科,江苏苏州215101

出　　处：《临床医学工程》2021年第12期1627-1628,共2页Clinical Medicine & Engineering

基　　金：江苏省中医药局科技项目(YB2017062)。

摘　　要：目的探讨血浆脂蛋白相关磷脂酶A_(2)(Lp-PLA_(2))水平评估冠心病患者病情及冠状动脉病变的临床价值。方法选取2016年3月至2017年9月我院收治的146例冠心病患者为疾病组,同期100例健康体检者为健康组,比较两组的血浆Lp-PLA_(2)水平。疾病组患者根据冠脉造影结果分为单支血管病变亚组、两支血管病变亚组及三支血管病变亚组,比较各亚组的血浆Lp-PLA_(2)水平;疾病组患者根据疾病类型分为稳定型心绞痛亚组、急性冠脉综合征亚组、缺血性心肌病亚组,比较各亚组的血浆Lp-PLA_(2)水平。结果疾病组的血浆Lp-PLA_(2)水平显著高于健康组(P<0.05)。三支血管病变亚组的血浆Lp-PLA_(2)水平显著高于单支血管病变亚组、两支血管病变亚组,两支血管病变亚组的血浆Lp-PLA_(2)水平显著高于单支血管病变亚组(P<0.05)。缺血性心肌病亚组的血浆Lp-PLA_(2)水平显著高于稳定型心绞痛亚组、急性冠脉综合征亚组,急性冠脉综合征亚组的血浆Lp-PLA_(2)水平显著高于稳定型心绞痛亚组(P<0.05)。结论冠心病患者的血浆Lp-PLA_(2)水平显著高于正常人群,与冠状动脉病变支数及疾病严重程度有显著关系,Lp-PLA_(2)可用以评估冠心病患者的病情及冠状动脉病变程度。Objective To explore the clinical value of plasma lipoprotein-associated phospholipase A_(2)(Lp-PLA_(2))level in the evaluation of disease condition and coronary artery lesions of patients with coronary artery disease.Methods 146 patients with coronary heart disease admitted to our hospital from March 2016 to September 2017 were selected as the disease group,and 100 healthy objects at the same period were selected as the healthy group;The plasma Lp-PLA_(2) levels of the two groups were compared.Patients in the disease group were divided into single-vessel lesion subgroup,two-vessel lesion subgroup and three-vessel lesion subgroup according to the results of coronary angiography,and the plasma Lp-PLA_(2) levels in each subgroup were compared;Patients in the disease group were divided into stable angina pectoris subgroup,acute coronary syndrome subgroup and ischemic cardiomyopathy subgroup according to the disease type;and the plasma Lp-PLA_(2) levels in each subgroup were compared.Results The plasma Lp-PLA_(2) level in the disease group was significantly higher than that in the healthy group(P<0.05).The plasma Lp-PLA_(2) level in the three-vessel lesion subgroup was significantly higher than that in the single-vessel lesion subgroup and the two-vessel lesion subgroup,and the plasma Lp-PLA_(2) level in the two-vessel lesion subgroup was significantly higher than that in the single-vessel lesion subgroup(P<0.05).The plasma Lp-PLA_(2) level in ischemic cardiomyopathy subgroup was significantly higher than that in stable angina pectoris subgroup and acute coronary syndrome subgroup,and the plasma Lp-PLA_(2) level in acute coronary syndrome subgroup was significantly higher than that in stable angina pectoris subgroup(P<0.05).Conclusions Plasma Lp-PLA_(2) level in patients with coronary heart disease is higher than that in normal people,which is significantly correlated with the number of coronary artery lesions and the severity of the disease.Lp-PLA_(2) can be used to evaluate the disease condition and severity of cor

关 键 词：脂蛋白相关磷脂酶A_(2) 冠心病 冠状动脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]