平阳霉素联合介入栓塞治疗颌面部血管瘤的有效性及安全性  

Efficacy and safety of pingyangmycin combined with interventional embolization in the treatment of maxillofacial hemangioma

作　　者：秦蕊 田国标 王玲[1] 刘轶琼 张苗 Qin Rui;Tian Guobiao;Wang Ling;Liu Yiqiong;Zhang Miao(Department of Dermatology,Armed Police Corps Hospital of Beijing,Beijing 100027,China;Department of Vascular Surgery,Beijing Friendship Hospital,Capital Medical University Pinggu Hospital,Beijing 101200,China;Preventive Health Care Unit of Outpatient Department,Armed Police Corps Hospital of Beijing,Beijing 100027,China)

机构地区：[1]武警北京总队医院皮肤科,北京100027 [2]首都医科大学附属北京友谊医院平谷医院血管外科,北京101200 [3]武警北京总队医院门诊部预防保健科,北京100027

出　　处：《血管与腔内血管外科杂志》2021年第9期1119-1122,1128,共5页Journal of Vascular and Endovascular Surgery

摘　　要：目的探讨平阳霉素联合介入栓塞治疗颌面部血管瘤的有效性及安全性。方法选取2018年5月至2020年5月于武警北京总队医院接受治疗的128例颌面部血管瘤患者,并依据随机数字表法将患者分为对照组和观察组,每组64例。对照组采用血管瘤腔内平阳霉素注射的治疗方法;观察组采用血管瘤腔内平阳霉素注射联合介入栓塞的治疗方法。比较两组患者于治疗前、治疗后1个月、治疗后3个月、治疗后6个月的血管瘤瘤体面积。比较两组患者治疗后1个月内的不良反应发生情况、治疗后6个月的满意度评分、治疗后6个月的治疗效果。结果治疗前,两组患者的血管瘤瘤体面积比较,差异无统计学意义(P>0.05)。治疗后1、3、6个月,观察组患者的血管瘤瘤体面积均小于对照组患者,差异均有统计学意义(P<0.05)。治疗后1个月内,观察组患者的总不良反应发生率为17.19%(11/64),与对照组患者10.94%(7/64)比较,差异无统计学意义(P>0.05)。治疗后6个月,观察组患者的皮肤颜色、血管瘤瘤体缩小程度和治疗整体效果的满意度评分均高于对照组患者,差异均有统计学意义(P<0.05)。治疗后6个月,观察组患者的治疗效果明显优于对照组患者,差异有统计系意义(P<0.05)。结论采用平阳霉素联合介入栓塞的方法治疗颌面部血管瘤,可以更加有效地缩小血管瘤瘤体面积,提高治疗效果及患者的治疗满意度,具有良好的安全性。Objective To explore the efficacy and safety of pingyangmycin combined with interventional embolization in the treatment of maxillofacial hemangioma.Method A total of 128 patients with maxillofacial hemangioma who were treated in Armed Police Corps Hospital of Beijing from May 2018 to May 2020 were selected.According to the method of random numbers,they were divided into control group and observation group,each with 64 cases.The control group was treated with hemangioma intracavitary injection of pingyangmycin.The observation group was treated with hemangioma intracavitary injection of pingyangmycin+interventional embolization.The hemangioma area of the two groups of patients was compared before treatment,1 month after treatment,3 months after treatment,and 6 months after treatment.The adverse reactions of the two groups were compared within 1 month after treatment,the satisfaction score at 6 months after treatment,and the treatment effect at 6 months after treatment.Result Before treatment,the difference in the area of hemangioma of the two groups of patients was not statistically significant(P>0.05).One month,three months,and six months after treatment,the area of hemangioma in the observation group was lower than that in the control group(P<0.05).Within one month after treatment,the total incidence of adverse reactions was 17.19%(11/64)in the observation group and 10.94%(7/64)in the control group.There was no significant difference between the two groups(P>0.05).At 6 months after treatment,patients in the observation group reported higher satisfaction scores(P<0.05).At 6 months after treatment,the satisfaction scores with respect to skin color,extent of hemangioma shrinkage,and overall efficacy of treatment than patients in the control group,all with statistically significant differences(P<0.05).The treatment effect of the observation group was better than that of the control group at 6 months after treatment(P<0.05).Conclusion The use of pingyangmycin combined with interventional embolization to treat maxillo

关 键 词：平阳霉素 介入栓塞 颌面部 血管瘤 血管内皮细胞 

分 类 号：R543[医药卫生—心血管疾病]