精子DNA碎片指数对辅助生殖技术妊娠结局的影响  

Effect of sperm DNA fragmentation index on pregnancy outcome in ART

作　　者：刘琳[1,2] 刘学润 李涛 高文欣[3] 岳丰 马晓玲[1,2] LIU Lin;LIU Xuerun;LI Tao;GAO Wenxin;YUE Feng;MA Xiaoling(The Reproductive Melicine Special Hospital,First Hospital of Lanzhou University,Ianzhou 730000,Gansu,China;Key Laboratory for Reproductive Medicine and Embryo of Gansu,Lanzhou 730000,Gansu,China;The First Clinical Medical College,Ianzhou University,Lanzhou730000,Gansu,China)

机构地区：[1]兰州大学第一医院生殖医学专科医院,兰州730000 [2]甘肃省生殖医学与胚胎重点实验室,兰州730000 [3]兰州大学第一临床医学院,兰州730000

出　　处：《中国性科学》2021年第12期6-9,共4页Chinese Journal of Human Sexuality

基　　金：国家自然科学基金地区项目(81960279);2020年度甘肃省高等学校创新基金(2020B-014);甘肃省科技厅一般项目(21JR1RA078);兰州大学第一医院院内基金(ldyyyn2018-55);兰州大学第一临床医学院卓越计划(20200060056)。

摘　　要：近年的研究认为,无论是自然受孕,还是通过辅助生殖技术(ART)助孕,男性生育力与精子DNA碎片指数(DFI)均呈负相关。世界首例试管婴儿诞生后,ART迅速发展,宫腔内人工授精(IUI)、体外受精-胚胎移植(IVF-ET)、卵胞浆内单精子注射(ICSI)等技术已广泛应用于临床。在ART的诊疗过程中,男性不育的评估主要取决于精液常规水平,而DFI作为一种有效诊断男性不育的补充指标,其所反映的DNA碎片化程度对ART结局的影响引起了许多学者的关注。本文就精子DFI对ART诊疗妊娠结局的影响作一综述。Relevant studies in recent years suggest that male fertility may be negatively correlated with sperm DNA fragmentation index(DFI) whether assisted reproduction technology(ART) or natural reproduction. After the birth of the world′s first test-tube baby, ART has developed rapidly, and now mainly including intrauterine insemination(IUI), in vitro fertilization and embryo transfer(IVF-ET), intracytosperm injection(ICSI) and other technologies. In the diagnosis and treatment process of ART, the assessment of male infertility mainly depends on semen routine. As an effective supplementary index of male infertility, DFI, which reflects the degree of DNA fragmentation, has attracted the attention of many scholars on the influence of ART outcome. This paper reviews the effect of sperm DFI on pregnancy outcome in ART treatment.

关 键 词：精子 DNA碎片指数 辅助生殖技术 妊娠结局 

分 类 号：R697[医药卫生—泌尿科学]