同源盒蛋白1在宫颈癌组织中的表达水平及临床意义  

Expression level and clinical significance of homologous box protein 1 in cervical carcinoma tissues

作　　者：胡飞红[1] 吴红莲[1] HU Feihong;WU Honglian(Department of Obstetrics and Gynecology,Lishui People's Hospital,Lishui 323000,Zhejiang,China)

机构地区：[1]丽水市人民医院妇产科,浙江丽水323000

出　　处：《中国性科学》2021年第12期50-53,共4页Chinese Journal of Human Sexuality

基　　金：浙江省医学会临床科研基金项目(2020ZYC-B48)。

摘　　要：目的研究同源盒蛋白1在宫颈癌组织中的表达水平及临床意义。方法选取2013年6月至2016年2月丽水市人民医院诊治的60例宫颈癌患者作为研究对象,获取其宫颈癌组织(宫颈癌组,n=60)及宫颈癌癌旁组织(癌旁组,n=60)。另选取同期由于宫颈良性病变进行组织病理学检查的30例患者,获取其正常宫颈组织(对照组,n=30)。采用免疫组织化学染色法检测三组的同源盒蛋白1表达水平,并分析其表达水平与宫颈癌患者临床特征的相关性,采用多因素回归分析影响宫颈癌患者预后的因素。结果宫颈癌组、癌旁组及对照组的同源盒蛋白1表达的阳性率分别为91.67%(55/60)、36.67%(22/60)、6.67%(2/30),差异具有统计学意义(P<0.05);同源盒蛋白1的表达水平与宫颈癌TNM分期、淋巴结转移及肿瘤的分化程度相关(P<0.05);同源盒蛋白1不同阳性表达水平中,强阳性、弱和中度阳性及阴性5年生存率分别为29.41%、57.14%和100.00%,同源盒蛋白1表达强阳性的5年生存率明显低于弱和中度阳性及阴性。多因素回归分析发现,年龄与宫颈癌患者的预后无明显相关(P=0.089),肿瘤分化程度、TNM分期、肿瘤有无淋巴结转移及同源核蛋白1的表达水平均与宫颈癌患者的预后相关(P<0.05)。结论同源盒蛋白1表达水平的升高与预后相关,可根据其表达水平预判宫颈癌患者的预后情况。Objective To study the expression level and clinical significance of homologous box protein 1 in cervical cancer tissue. Methods 60 patients with cervical cancer diagnosed and treated in Lishui People′s Hospital from June 2013 to February 2016 were selected as the research subjects, and their cervical cancer tissues(cervical cancer group, n=60) and adjacent cervical cancer tissues(adjacent cancer group, n=60) were obtained. Normal cervical tissues were obtained from 30 patients who underwent histopathological examination due to benign cervical lesions during the same period(control group, n=30). Immunohistochemical staining was used to detect the expression level of homologous box protein 1 in the three groups, and the correlation between the expression level and clinical characteristics of cervical cancer patients was analyzed. Multivariate regression analysis was used to analyze the prognostic factors of cervical cancer patients. Results The positive rate of homologous box protein 1 expression in cervical cancer group, adjacent cancer group and control group was 91.67%(55/60), 36.67%(22/60) and 6.67%(2/30), respectively, with statistical significance(P<0.05). The expression level of homologous box protein 1 was correlated with TNM stage, lymph node metastasis and tumor differentiation of cervical cancer(P<0.05). In different positive expression levels of homolobox protein 1, the 5-year survival rates of strong positive, weak and moderate positive, and negative were 29.41%, 57.14% and 100.00%, respectively. The 5-year survival rate of strongly positive homolobox 1 expression was significantly lower than that of weak and moderate positive and negative homolobox 1 expression. Multivariate regression analysis showed that there was no significant correlation between age and prognosis of cervical cancer patients(P=0.089), but the degree of tumor differentiation, TNM stage, lymph node metastasis and expression level of nucleoprotein 1 were all correlated with prognosis of cervical cancer patients(P<0.05). Conclusion

关 键 词：同源盒蛋白1 宫颈癌 表达水平 

分 类 号：R711[医药卫生—妇产科学]