血清白细胞介素-26水平、肝功能相关指标与慢性丙型肝炎患者预后的相关性探讨  

Correlation Analysis of Serum Interleukin-26 Level,Liver Function Related Indexes and Prognosis of Patients with Chronic Hepatitis C

作　　者：周汉义 熊振芳 朱建光[1] ZHOU Han-yi;XIONG Zhen-fang;ZHU Jiang-guang(Department of Clinical Laboratory,Xianning Central Hospital,The First Affiliated Hospital of Hubei University of Science and Technology,Xianning Hubei 437100,China)

机构地区：[1]咸宁市中心医院/湖北科技学院附属第一医院检验科,湖北咸宁437100

出　　处：《湖北科技学院学报（医学版）》2021年第6期501-504,共4页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：2019年咸宁市自然科学基金指导项目(2019XY034);咸宁市中心医院院级科研重点项目(2018XYA004)。

摘　　要：目的通过检测慢性丙型肝炎患者血清中白细胞介素-26(IL-26)、C-反应蛋白(CRP)、总胆红素(TBIL)、谷丙转氨酶(ALT)、天冬氨酸氨基转移酶(AST)等水平,探讨血清IL-26、肝功能相关指标与慢性丙型肝炎患者预后的相关性和存在的潜在意义。方法选取本院就诊的慢性丙型肝炎患者140例,其中高病毒载量慢性丙型肝炎患者68例(高病毒组),低病毒载量慢性丙型肝炎患者72例(低病毒组);慢性丙型肝炎患者进展为肝硬化、失代偿肝硬化、肝衰竭或肝癌的55例患者为不良预后组,未发生进展的85例患者非不良预后组。另随机选取同期于本院进行体检的健康人群140例为对照组。采用全自动生化分析仪检测血清AST、ALT及TBIL水平;采用免疫比浊法测定CRP水平;采用酶联免疫吸附(ELISA)法检测血清IL-26水平;采用Logistic回归分析影响慢性丙型肝炎患者发生不良预后的危险因素。结果高病毒组与低病毒组慢性丙型肝炎患者血清IL-26、CRP、TBIL、ALT、AST水平均显著高于对照组,且高病毒组显著高于低病毒组(P<0.05);不良预后组血清CRP、TBIL、ALT、AST及IL-26水平均显著高于非不良预后组(P<0.05);Logistic回归分析结果显示,血清CRP、ALT、AST及IL-26水平均是影响慢性丙型肝炎患者发生不良预后的独立危险因素(P<0.05)。结论慢性丙型肝炎患者血清IL-26水平升高,且与患者病毒载量正相关;血清CRP、ALT、AST及IL-26均与患者预后存在一定相关性,可能是评估慢性丙型肝炎患者预后的潜在参考指标。Objective To detect the level of interleukin-26(IL-26),C-reactive protein(CRP),total bilirubin(TBIL),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)in the serum of patients with chronic hepatitis C,and to explore the correlation and potential significance of serum IL-26,liver function-related indicators and the prognosis of patients with chronic hepatitis C.Methods A total of 140 patients with chronic hepatitis C in our hospital were selected,including 68 patients with high viral load chronic hepatitis C(high virus group),72 patients with low viral load chronic hepatitis C(low virus group),55 patients with chronic hepatitis C progressing to cirrhosis,decompensated cirrhosis,liver failure or liver cancer(poor prognosis group),and 85 patients without progression(non poor prognosis group).In addition,140 healthy people who underwent physical examination in our hospital during the same period were randomly selected as the control group.Serum AST,ALT and TBIL levels were measured by using a automatic biochemical analyzer;serum CRP levels were detected by immunoturbidimetry;serum IL-26 levels were detected by enzyme-linked immunosorbent assay(ELISA);Logistic regression analysis was used to analyze the risk factors of adverse prognosis in patients with chronic hepatitis C.Results The levels of serum IL-26,CRP,TBIL,ALT,and AST in patients with chronic hepatitis C in the high virus group and the low virus group were significantly higher than those in the control group,while those in the high virus group was significantly higher than those in the low virus group(P<0.05);the levels of serum CRP,TBIL,ALT,AST and IL-26 in the poor prognosis group were significantly higher than those in the non poor prognosis group(P<0.05);the results of Logistic regression analysis showed that the levels of serum CRP,ALT,AST,and IL-26 were independent risk factors affecting the poor prognosis of patients with chronic hepatitis C(P<0.05).Conclusion Serum IL-26 levels in patients with chronic hepatitis C increase and are posit

关 键 词：慢性丙型肝炎 白细胞介素-26 C-反应蛋白 总胆红素 谷丙转氨酶 天冬氨酸氨基转移酶 预后 

分 类 号：R512.6[医药卫生—内科学]