连续性血液净化治疗肾综合征出血热合并急性肾功能衰竭的临床价值探究  

Clinical value of continuous blood purification in the treatment of hemorrhagic fever with renal syndrome complicated with acute renal failure

作　　者：阚玉 KAN Yu(Shenyang Sixth People’s Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市第六人民医院,110000

出　　处：《中国实用医药》2021年第35期8-11,共4页China Practical Medicine

摘　　要：目的探讨连续性血液净化治疗肾综合征出血热合并急性肾功能衰竭的临床价值。方法98例肾综合征出血热合并急性肾功能衰竭患者,按照血液净化方法不同分为观察组和对照组,每组49例。对照组患者采用普通血液透析治疗,观察组患者采用连续性血液透析治疗。比较两组患者生存况及治疗前后血小板计数(PLT)、B型脑钠肽(BNP)、肾功能指标[血尿素氮(BUN)、血肌酐(Scr)]、血流动力学指标[中心静脉压(CVP)、心率(HR)、心输出量(CO)]以及炎症指标[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6及IL-8]水平。结果随访1年,观察组患者生存率为100.00%,高于对照组的91.84%,差异具有统计学意义(P<0.05)。治疗后,两组患者PLT高于本组治疗前,BNP水平低于本组治疗前,且观察组患者PLT(105.31±45.26)×10^(9)/L高于对照组的(69.31±40.26)×10^(9)/L,BNP水平(110.26±20.54)pg/ml低于对照组的(126.85±37.49)pg/ml,差异具有统计学意义(P<0.05)。治疗后,两组患者BUN、Scr水平低于本组治疗前,且观察组患者BUN、Scr水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者CVP、HR、CO均低于本组治疗前,且观察组患者均低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者TNF-α、IL-1β、IL-6以及IL-8水平均低于本组治疗前,且观察组患者均低于对照组,差异具有统计学意义(P<0.05)。结论连续性血液净化治疗肾综合征出血热合并急性肾功能衰竭患者具有良好的治疗效果,值得临床推广应用。Objective To discuss the clinical value of continuous blood purification in the treatment of hemorrhagic fever with renal syndrome complicated with acute renal failure.Methods A total of 98 patients with hemorrhagic fever with renal syndrome and acute renal failure were divided into observation group and control group according to different blood purification methods,with 49 cases in each group.Patients in the control group were treated with ordinary hemodialysis,and patients in the observation group were treated with continuous blood hemodialysis.Both groups were compared in terms of survival conditions,platelet count(PLT),brain natriuretic peptide(BNP),renal function indexes[blood urea nitrogen(BUN),blood creatinine(Scr)],hemodynamic indexes[central vein pressure(CVP),heart rate(HR),cardiac output(CO)]and inflammation indicators[tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-6 and IL-8]before and after treatment.Results After 1 year of follow-up,the survival rate in the observation group was 100.00%,which was higher than 91.84%in the control group,and the difference was statistically significant(P<0.05).After treatment,the PLT of the two groups was higher than that of this group before treatment,and the BNP was lower than that of this group before treatment;the PLT(105.31±45.26)×10^(9)/L of the observation group was higher than(69.31±40.26)×10^(9)/L of the control group,and the BNP(110.26±20.54)pg/ml was lower than(126.85±37.49)pg/ml of the control group;all the differences were statistically significant(P<0.05).After treatment,the BUN and Scr of the two groups were lower than those of this group before treatment,and the BUN and Scr of the observation group were lower than those of the control group.All the differences were statistically significant(P<0.05).After treatment,the CVP,HR and CO of the two groups were lower than those of this group before treatment,and the observation group was lower than the control group.All the differences were statistically significant(P<0.05).After treatment,the

关 键 词：连续性血液净化 肾综合征出血热 急性肾功能衰竭 治疗效果 

分 类 号：R512.8[医药卫生—内科学] R692.5[医药卫生—临床医学]