Targeted prebiotics alter the obese gut microbiome in humans  

作　　者：Junjun She Chi Chun Wong Jun Yu 

机构地区：[1]Department of General Surgery,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,Shaanxi,China [2]Center for Gut Microbiome Research,Med-X Institute,The First Affiliated Hospital of Xi’an Jiao tong University,Xi’an,Shaanxi,China [3]Institute of Digestive Disease and Department of Medicine and Therapeutics,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong,Hong Kong SAR,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第11期3163-3164,共2页信号转导与靶向治疗（英文）

基　　金：This work was supported by RGC Theme-based Research Scheme Hong Kong(T21-705/20-N);RGC-CRF Hong Kong(C4039-19GF);RGC-GRF(24100520,14101917,14108718);Heath and Medical Research Fund(06170686,08190706);Vice-Chancellor’s Discretionary Fund Chinese University of Hong Kong.

摘　　要：A recent study published in Nature by Delannoy-Bruno et al.1 described the role of formulated fibre snacks on the obese gut microbiome utilizing mouse-human co-clinical trial,and demonstrated that precise dietary fibre intervention directed at the obese gut microbiome modulates the host’s physiological state.Epidemiological and observational studies2 have long linked a diet rich in fibre to protection against chronic diseases.Dietary fibre functions as a prebiotic that can be utilized by gut microbes.Given accumulating evidence showing roles of gut microbes in health and disease,there is renewed interest in harnessing fibre as a prebiotic to promote a healthy gut microbiome.Dietary fibres are safe,inexpensive,and readily incorporated into our diet.However,the development of evidenced-based fibre preparations that selectively induce the abundance of desirable gut microbes pose a huge challenge,as fibre and the gut microbiome are complex identities that remain poorly characterized.This is confounded by their dynamic interactions and inter-and intra-personal variations.

关 键 词：BRUNO fibre utilizing 

分 类 号：R589.2[医药卫生—内分泌]