帕金森病神经发生的研究进展  

Research Progress on Neurogenesis in Parkinson’s Disease

作　　者：吴铮 任志伟[1] 张国君[1,2] WU Zheng;REN Zhi-wei;ZHANG Guo-jun(Department of Functional Neurosurgery,Xuanwu Hospital Capital Medical University,Beijing 100053,China;Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China)

机构地区：[1]首都医科大学宣武医院功能神经外科,中国北京100053 [2]国家儿童医学中心首都医科大学附属北京儿童医院,中国北京100045

出　　处：《生命科学研究》2021年第6期504-508,共5页Life Science Research

基　　金：北京医院管理中心“登峰”计划专项经费资助项目(DFL20190801)。

摘　　要：帕金森病是一种黑质多巴胺能神经元丢失的神经退行性疾病。目前,临床治疗仅能缓解患者的运动症状,尚且没有阻止和逆转帕金森病变的有效办法。神经干细胞是动物脑内能够自我更新、增殖和分化的一组多潜能细胞。近年来,有证据表明帕金森病患者以及动物模型脑内存在着神经干细胞,它们在特定条件下能够生成多巴胺能神经元。因此,促进内源性神经干细胞再生修复对挽救多巴胺能神经元丢失以及缓解运动症状具有巨大的潜力,可能成为治疗帕金森病的有力武器。本文总结了帕金森病患者和动物模型中神经干细胞增殖与分化的相关研究,以期为促神经发生治疗帕金森病提供思路。Parkinson’s disease(PD)is a neurodegenerative disease characterized by dopaminergic neuronal loss in the substantia nigra.At present,motor symptoms can be alleviated clinically,but there is no effective way to prevent and reverse the progression of PD.Neural stem cells are a group of pluripotent cells capable of self-renewal,proliferation and differentiation in animal brains.In recent years,there has been much evidence proving that there are neural stem cells in PD patients and animal models,which can generate new dopaminergic neurons in a particular condition.Therefore,promoting the regeneration of neural stem cells has a great potential for rescuing the loss of dopaminergic neurons and relieving motor symptoms,which maybe a powerful weapon in PD treatment.This review summarized the proliferation and differentiation of neural stem cells in PD patients and animal models.It may provide novel ideas for the neurogenic therapy of PD.

关 键 词：帕金森病(PD) 神经发生 神经干细胞(NSC) 室管膜下区(SVZ) 

分 类 号：Q426[生物学—神经生物学] R742.5[生物学—生理学]