动物细小病毒新型疫苗研究进展  

Progress in Development of Novel Vaccines Against Parvoviruses

作　　者：曾星翔 汪铭书 程安春[1,2,3] ZENG Xing-xiang;WANG Ming-shu;CHENG An-chun(Institute of Preventive Veterinary Medicine,College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,Sichuan,China;Research Center of Avian Diseases,College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,Sichuan,China;Key Laboratory of Animal Diseases and Human Health of Sichuan Province,Sichuan Agricultural University,Chengdu 611130,Sichuan,China)

机构地区：[1]四川农业大学动物医学院预防兽医研究所,中国四川成都611130 [2]四川农业大学动物医学院禽病防治研究中心,中国四川成都611130 [3]四川农业大学动物疫病与人类健康四川省重点实验室,中国四川成都611130

出　　处：《生命科学研究》2021年第6期514-519,525,共7页Life Science Research

基　　金：财政部和农业农村部:国家现代农业产业技术体系资助项目;国家农业产业技术体系四川兽药创新团队专项(SCCXTD-2021-18)。

摘　　要：细小病毒是动物病毒中最小最简单的一类单链线状DNA病毒,其在自然界的宿主范围广,感染后呈长期隐性感染,对畜牧养殖业有重要影响。目前,对细小病毒的防治仍以接种减毒疫苗和灭活疫苗为主,但它们仍存在一些不足,如:灭活疫苗成本高;减毒疫苗存在返强的可能性。因此,研制更安全、高效、制备方便的新型疫苗是未来研究的趋势。本文介绍了新型疫苗的发展概况以及近年来细小病毒新型疫苗的研究进展,以期为细小病毒新型疫苗的研究及应用提供参考。Parvoviruses are the smallest and simplest single-stranded linear DNA viruses among animal viruses.They have a wide host range in nature,causing a long-lasting and inapparent infection and having a big impact on livestock farming.The current commercial vaccines,including inactivated vaccines and attenuated live vaccines,exhibit some defects.The former is costly,and the latter may have a risk of reversion to virulence.Thus,novel vaccines that are safer,more efficient and easier to prepare should be developed in future research.Herein,an overview of novel vaccines and the recent progress in parvovirus vaccine are provided,which would be helpful to further research and application of vaccines against parvoviruses.

关 键 词：细小病毒 新型疫苗 DNA疫苗 亚单位疫苗 重组活病毒载体疫苗 

分 类 号：Q819[生物学—生物工程] S852.659.2[农业科学—基础兽医学]