分子印迹技术在电化学传感领域的应用研究进展  

Research Progress of the Molecular Imprinting Technology in Electrochemical Sensing

作　　者：程寿年 任书芳 冯润妍 王庆涛[1] 郑志祥 CHENG Shounian;REN Shufang;FENG Runyan;WANG Qingtao;ZHENG Zhixiang(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070;Key Laboratory of Evidence Science Techniques Research and Application of Gansu Province,Forensic Expertise Center,Gansu University of Political Science and Law,Lanzhou 730070)

机构地区：[1]西北师范大学化学化工学院,甘肃兰州730070 [2]甘肃政法大学,甘肃省证据科学技术研究与应用重点实验室,司法鉴定中心,甘肃兰州730070

出　　处：《分析科学学报》2021年第6期819-827,共9页Journal of Analytical Science

基　　金：国家自然科学基金(No.51862029,21865032);甘肃省科技计划(No.20JR5RA173);兰州市人才创新创业项目(No.2019-RC-99);甘肃政法大学司法鉴定中心科研项目(No.jdzxzd2018-02)。

摘　　要：本文对近十年来分子印迹电化学传感器的制备技术,以及电化学传感器检测方法的最新研究进展进行了综述。重点介绍了分子印迹技术及策略在电化学传感领域的最新应用进展;特别关注了近几年出现的特殊分子印迹策略,例如:表面分子印迹技术、纳米分子印迹技术、多模板分子印迹技术、多功能单体分子印迹技术,以及替代模板分子印迹技术等。对不同类型分子印迹电化学传感器(电流型、电导型、电位型、电容型等)在环境污染物、生物分子、食品添加剂、药物残留等方面的应用进行了介绍。最后对分子印迹电化学传感器目前面临的问题进行了概述,展望了其未来发展方向。Combining molecular imprinting technology and electrochemical sensing,molecular imprinting electrochemical sensor(MIES) affords the advantages of specific selectivity,high sensitivity,high stability,simple structure,feasibility and convenience,low cost,and easy miniaturization,which make MIES obtain extensive attention in environmental testing,biomedicine,food safety etc.This review gives a comparative overview of the development of the preparation technology and detection methods of MIES in the past ten years.It focuses on the latest application progress of molecular imprinting technologies and strategies in the field of electrochemical sensing.Special attention has been paid to the special molecular imprinting strategies emerged in recent years,such as surface molecular imprinting technology,nano molecular imprinting technology,multi-templates molecular imprinting technology,multifunctional monomer molecular imprinting technology and virtual template imprinting technology.The applications of different types of MIES(current type,conductivity type,potential type,capacitance type,etc.) in environmental pollutants,biomolecules,food additives,drug residues,etc.are introduced.Finally,the current problems faced by MIES are summarized,and the future development of this technology is prospected.

关 键 词：分子印迹 电化学传感器 特殊分子印迹策略 

分 类 号：O657.1[理学—分析化学]