Recent advances in tissue stem cells  

作　　者：Xin Fu Qiang He Yu Tao Mengdi Wang Wei Wang Yalong Wang Qing Cissy Yu Fang Zhang Xiaoyu Zhang Ye-Guang Chen Dong Gao Ping Hu Lijian Hui Xiaoqun Wang Yi Arial Zeng 

机构地区：[1]State Key Laboratory of Cell Biology,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China [2]Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200233,China [3]State Key Laboratory of Brain and Cognitive Science,CAS Center for Excellence in Brain Science and Intelligence Technology,Bioland Laboratory(Guangzhou),Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China [4]University of Chinese Academy of Sciences,Beijing 100049,China [5]The State Key Laboratory of Membrane Biology,Tsinghua-Peking Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing 100084,China [6]Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine,Guangzhou Regenerative Medicine and Health Guangdong Laboratory,Guangzhou 510530,China [7]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China [8]Bio-Research Innovation Center,Shanghai Institute of Biochemistry and Cell Biology,Suzhou 215121,China [9]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China [10]School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Hangzhou 310024,China [11]Advanced Innovation Center for Human Brain Protection,Beijing Institute for Brain Disorders,Capital Medical University,Beijing 100069,China

出　　处：《Science China(Life Sciences)》2021年第12期1998-2029,共32页中国科学（生命科学英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(31988101 and 31730056 to YGC;32125013 and 81772723 to DG;32170804 to PH;31930030 to LH;91732301,31671072,31771140,81891001,91432111,81527901,31400977,31625013 to XW;31625020,31830056,31861163006 to YAZ);the Ministry of Science and Technology of China(2017YFA0103601 to YGC;2020YFA0509000,2017YFA0505500 to DG;2017YFA0102700 to PH;2019YFA0802001,2019YFA0801503 to LH;2017YFA0102601,2019YFA0110100 to XW;2020YFA0509002,2019YFA0802002 to YAZ);the Strategic Priority Research Program of the Chinese Academy of Science(XDA16020400 to PH;XDA16020200 to YAZ);the Shanghai Science and Technology Commission(21XD1424200,21ZR1470100 to DG);the Basic Frontier Science Research Program of Chinese Academy of Sciences(ZDBS-LY-SM015 to DG);Space Medical Experiment Project of China Manned Space Program(HYZHXM01017 to PH);the Grants of Beijing Brain Initiative of Beijing Municipal Science&Technology Commission(Z181100001518004 to XW)。

摘　　要：Stem cells are undifferentiated cells capable of self-renewal and differentiation,giving rise to specialized functional cells.Stem cells are of pivotal importance for organ and tissue development,homeostasis,and injury and disease repair.Tissue-specific stem cells are a rare population residing in specific tissues and present powerful potential for regeneration when required.They are usually named based on the resident tissue,such as hematopoietic stem cells and germline stem cells.This review discusses the recent advances in stem cells of various tissues,including neural stem cells,muscle stem cells,liver progenitors,pancreatic islet stem/progenitor cells,intestinal stem cells,and prostate stem cells,and the future perspectives for tissue stem cell research.

关 键 词：neural stem cells muscle stem cells liver progenitors pancreatic islet stem/progenitor cells intestinal stem cells prostate stem cells 

分 类 号：Q25[生物学—细胞生物学]