盐酸利托君联合硫酸镁治疗先兆早产效果及对促肾上腺皮质素释放激素、炎症水平影响  

Effect of ritodrine hydrochloride combined with magnesium sulfate in the treatment of threatened premature delivery and its influence on corticotropin releasing hormone and inflammation

作　　者：魏婉 Wei Wan(The first Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471000)

机构地区：[1]河南科技大学第一附属医院,河南洛阳471000

出　　处：《辽宁医学杂志》2021年第6期24-27,共4页Medical Journal of Liaoning

摘　　要：目的探究盐酸利托君联合硫酸镁治疗先兆早产效果及对促肾上腺皮质素释放激素(CRH)、炎症水平影响。方法选取2018年1月至2020年7月我院收治的65例先兆早产患者为研究对象,按照随机数字表法分为对照组(n=32例)和观察组(n=33例),对照组使用硫酸镁治疗,观察组在对照组基础上联合盐酸利托君治疗。对比两组患者用药后治疗效果、妊娠结局及治疗前后CRH浓度、炎症因子水平、不良反应。结果观察组治疗总有效率(96.97%)明显高于对照组(81.25%,P<0.05);治疗前两组患者CRH浓度及C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平对比无差异(P>0.05),治疗后两组患者CRH浓度及CRP、TNF-α、IL-6水平均有下降(P<0.05),且观察组低于对照组(P<0.05);观察组患者妊娠延长时间多于对照组(P<0.05);产后出血量少于对照组(P<0.05);产后新生儿评分高于对照组(P<0.05)。两组不良反应差异无统计学意义(P>0.05)。结论盐酸利托君联合硫酸镁治疗先兆早产,可显著提高治疗效果,改善CRH浓度、炎症因子水平,有助于提高妊娠结局,有很好临床价值。Objective To explore the effect of ritodrine hydrochloride combined with magnesium sulfate in the treatment of threatened preterm labor and the effect on corticotropin releasing hormone(CRH)and inflammation levels.Methods The 65 patients with threatened preterm birth admitted to our hospital from January 2018 to July 2020 were selected as the research objects,and were divided into the control group(n=32 cases)and the observation group(n=33 cases)according to the random number table method.The control group was treated with magnesium sulfate,and the observation group was treated with ritodrine hydrochloride on the basis of the control group.The treatment effect,pregnancy outcome,CRH concentration,adverse reactions and inflammatory factor levels before and after treatment were compared between the two groups of patients.Results The total effective rate of treatment in the observation group(96.97%)was significantly higher than that of the control group(81.25%,P<0.05);the CRH concentration,C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)of the two groups before treatment There was no difference in the level of interleukin-6(IL-6)(P>0.05).After treatment,the CRH concentration and the levels of CRP,TNF-αand IL-6 in the two groups decreased(P<0.05),and The observation group was significantly lower than the control group(P<0.05);the observation group had longer pregnancy extension time than the control group(P<0.05);the postpartum hemorrhage was less than the control group(P<0.05);the postpartum neonatal score was higher than the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The combination of ritodrine hydrochloride and magnesium sulfate in the treatment of threatened preterm labor can significantly improve the therapeutic effect,improve the concentration of CRH and the level of inflammatory factors,help improve pregnancy outcome,and has good clinical value.

关 键 词：盐酸利托君 硫酸镁 先兆早产 促肾上腺皮质素释放激素 炎症因子 

分 类 号：R714.21[医药卫生—妇产科学]