还原型谷胱甘肽联合恩替卡韦治疗乙肝肝硬化的效果以及对患者T淋巴细胞亚群的影响观察  

Observation of the effect of reduced glutathione combined with entecavir in the treatment of hepatitis B cirrhosis and its effect on T lymphocyte subsets

作　　者：常文娟[1] 王慧[1] 张艳鹤[1] Chang Wenjuan;Wang Hui(Zhang Yanhe,People′s Hospital of Jiaozuo City,Jiaozuo,Henan 454000)

机构地区：[1]焦作市人民医院,河南焦作454000

出　　处：《辽宁医学杂志》2021年第6期50-52,共3页Medical Journal of Liaoning

摘　　要：目的探讨还原型谷胱甘肽联合恩替卡韦治疗乙肝肝硬化的效果以及对患者T淋巴细胞亚群的影响:方法选取医院2017年1月-2019年1月期间接受治疗的130例乙肝肝硬化患者,根据随机数字表法,分成两组,各65例,两组患者治疗期间均给予保肝药物治疗,对照组:恩替卡韦0.5mg/次,口服,1次/日。观察组在对照组的基础上加用还原型谷胱甘肽0.6g/次,肌肉注射,1次/日。两组均连续治疗3个月,比较两组患者治疗前后的肝功能、肝纤维化以及T淋巴细胞亚群指标水平,评价治疗效果。结果治疗后,观察组肝功能、肝纤维化水平均低于对照组(P<0.05);观察组T淋巴细胞亚群水平均高于对照组(P<0.05);观察组的总有效率为78.46%,高于对照组61.54%(P<0.05)。结论还原型谷胱甘肽联合恩替卡韦治疗乙肝肝硬化,能够提高患者的肝功能、延缓肝纤维化,还可以改善患者的免疫功能,缓解乙肝肝硬化,疗效确切,值得推广。Objective To explore the effect of reduced glutathione combined with entecavir in the treatment of hepatitis B cirrhosis and its impact on patients′T lymphocyte subsets:Methods Select 130 patients with hepatitis B who received treatment in the hospital from January 2017 to January 2019 The patients with cirrhosis were divided into two groups according to the random number table method,each with 65 cases.The patients in both groups were treated with hepatoprotective drugs during the treatment period.The control group:entecavir 0.5 mg/time,orally,once/day.The observation group added 0.6 g/time of reduced glutathione on the basis of the control group,intramuscularly,once/day.The two groups were treated continuously for 3 months.The liver function,liver fibrosis and T lymphocyte subgroup index levels of the two groups of patients before and after treatment were compared to evaluate the treatment effect.Results After treatment,the liver function and liver fibrosis in the observation group were significantly lower than those in the control group(P<0.05);the T lymphocyte subsets in the observation group were significantly higher than the control group(P<0.05);The effective rate was 78.46%,significantly higher than the control group 61.54%(P<0.05).Conclusion Reduced glutathione combined with entecavir in the treatment of hepatitis B cirrhosis can improve the liver function of patients and delay liver fibrosis.It can also improve the patient′s immune function and relieve hepatitis B cirrhosis.The curative effect is definite and worth promoting.

关 键 词：乙肝肝硬化 还原型谷胱甘肽 恩替卡韦 肝功能 肝纤维化 T淋巴细胞亚群 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]