两个三(邻溴苄基)锡羧酸酯的合成、结构及抗肿瘤活性  

Synthesis, Structure and Antitumor Activity of Two Tris(o⁃bromobenzyl)tin Carboxylates

作　　者：刘熙 张复兴 何丽芳 李达伟 曾维鸿 江叔沄 贺霞 盛良兵 朱小明 LIU Xi;ZHANG Fu-Xing;HE Li-Fang;LI Da-Wei;ZENG Wei-Hong;JIANG Shu-Yun;HE Xia;SHENG Liang-Bing;ZHU Xiao-Ming(Department of Chemistry and Material Science,Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province,Key Laboratory of Functional Organometallic Materials of Colleges of Hunan Province,Hengyang Normal University,Hengyang,Hunan 421008,China)

机构地区：[1]衡阳师范学院化学与材料科学学院,功能金属有机化合物湖南省重点实验室,金属有机新材料湖南省普通高等学校重点实验室,衡阳421008

出　　处：《无机化学学报》2022年第1期46-52,共7页Chinese Journal of Inorganic Chemistry

基　　金：湖南省教育厅重点项目(No.19A070);湖南省高校创新平台开放基金项目(No.18K089);湖南省重点实验室开放基金(No.M018K07);湖南省应用特色学科基金、湖南省高校科技创新团队支持计划、衡阳市科技局项目和湖南省大学生创新创业训练计划项目资助。

摘　　要：合成了2个有机锡羧酸酯化合物三(邻溴苄基)锡噻吩2⁃甲酸酯(1)和三(邻溴苄基)锡肉桂酸酯(2)。通过元素分析、红外光谱、核磁共振谱(^(1)H、^(13)C和^(119)Sn)、差热分析、X射线单晶衍射方法对1和2进行了结构表征,对其结构进行了量子化学从头计算。结果显示,化合物1和2均为单锡核结构,锡原子均为四配位的畸变四面体构型。体外抗癌活性研究表明化合物1和2对人乳腺癌细胞(MCF⁃7)、人非小细胞肺癌细胞(A549)和人大细胞肺癌细胞(H460)均显示出较强的抑制活性。Two organotin carboxylate compounds,tri(o⁃bromobenzyl)tin thiophene 2⁃carboxylate(1)and tri(o⁃bromo⁃benzyl)tin cinnamate(2),have been synthesized.Compounds 1 and 2 were characterized by elemental analysis,IR spectroscopy,NMR(^(1)H,^(13)C,and ^(119)Sn),thermogravimetric analysis,and single⁃crystal X⁃ray diffraction.The study on compounds 1 and 2 has been performed with quantum chemistry calculation and in vitro anticancer activity.The results showed that the tin atoms in compounds 1 and 2 have distorted tetrahedral geometry.Compounds 1 and 2 had strong inhibitory activities against human breast cancer cells(MCF⁃7),human non⁃small cell cancer cells(A549),and human lung cancer cell lines(H460).CCDC:2109938,1;2109939,2.

关 键 词：三(邻溴苄基)锡噻吩2⁃甲酸酯 三(邻溴苄基)锡肉桂酸酯 晶体结构 量子化学 体外抗肿瘤活性 

分 类 号：O614.432[理学—无机化学]