基于交感神经系统的高血压非药物治疗研究现状和进展  

Current opinions and developments of non-pharmacological treatments of hypertension based on sympathetic nervous system

作　　者：叶鹏 谭兴[1] 冷岳奇 王杨凯[1] 王伟忠[1] YE Peng;TAN Xing;LENG Yueqi;WANG Yangkai;WANG Weizhong(Department of Marine Biomedicine and Polar Medicine,Naval Medical Center,Naval Medical University(Second Military Medical University),Shanghai 200433,China)

机构地区：[1]海洋生物医药与极地医学研究室,海军军医大学(第二军医大学)海军特色医学中心,上海200433

出　　处：《中国临床药理学与治疗学》2021年第12期1335-1343,共9页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(81970354,81630012,81800366)。

摘　　要：高血压病是一种危害人类健康的严重疾病,尽管高血压的临床治疗已经取得较好疗效,但仍存在不少药物耐受性等不同类型的顽固性高血压,而且高血压的并发症如心力衰竭、脑卒中等发病率仍居高不下,因此,非药物治疗策略的深入研发与应用已成为高血压治疗的一个重要方面。交感神经系统在高血压发生发展中起着关键性作用,目前大多数高血压防治的非药物治疗技术主要通过靶向调节机体交感神经功能来实现,这些技术主要包括深部脑刺激、肾动脉神经射频消融术、中央髂动静脉吻合术、压力反射激活疗法、血管内压力反射放大疗法、颈动脉体切除术等。本综述重点对上述基于交感神经系统的非药物治疗方法的应用现状和相关优缺点进行回顾总结,为高血压的有效治疗提供新思路和多重选择。Hypertension is a serious disease that endangers human health. Although the clinical efficiency of anti-hypertensive drugs have achieved good results, there are still many different types of resistant hypertension such as drug tolerance, and the incidence of complications of hypertension such as heart failure and stroke is still high. Therefore, the development and application of non-pharmacological treatment strategies have become an important aspect of the treatment of hypertension. The sympathetic nervous system plays a key role in the pathogenesis of hypertension. At present, most non-pharmacological treatment technologies for the prevention and treatment of hypertension mainly target the sympathetic nerve function. These technologies mainly include deep brain stimulation and renal denervation. Central iliac arteriovenous anastomosis, baroreflex activation therapy, endovascular baroreflex amplification, carotid body ablation, etc. This review focuses on the application status and related advantages and disadvantages of the above-mentioned non-pharmacological treatment methods based on the sympathetic nervous system, and provides new ideas and multiple options for treatment of hypertension.

关 键 词：高血压 交感神经调控 非药物治疗 

分 类 号：R544.1[医药卫生—心血管疾病]