利妥昔单抗联合糖皮质激素治疗难治性大疱性类天疱疮一例  

Rituximab combined with glucocorticoid in the treatment of refractory bullous pemphigoid:a case report

作　　者：陈雪[1] 谭城[1] 单敏洁[1] 闵仲生[1] 吉津[1] 陈芳[1] 刘青 吴皞 潘永正[1] CHEN Xue;TAN Cheng;SHAN Minjie;MIN Zhongsheng;JI Jin;CHEN Fang;LIU Qing;WU Hao;PAN Yongzheng(Department of Dermatology,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China;Department of Oncology,the Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]南京中医药大学附属医院皮肤科,江苏南京210029 [2]南京医科大学附属江宁医院肿瘤科,江苏南京210000

出　　处：《中国麻风皮肤病杂志》2022年第3期185-188,共4页China Journal of Leprosy and Skin Diseases

摘　　要：患者,男,35岁。四肢红斑、丘疹、水疱1个月。行皮肤组织病理、直接、间接免疫荧光及盐裂试验,符合大疱性类天疱疮诊断。予系统运用糖皮质激素,环磷酰胺冲击,联合吗替麦考酚酯、沙利度胺、静注人免疫球蛋白等治疗,疗效欠佳,改用利妥昔单抗联合糖皮质激素治疗后,病情好转。A 35-year-old male presented with erythema,papules and blisters on the lower extremitie for 1 month.The features of pathology,direct and indirect immunofluorescence and salt cracking test were in accordance with bullous pemphigoid.The efficacy of glucocorticoid,cyclophosphamide,combined with mycophenolate mofetil,thalidomide and intravenous injection of human immunoglobulin was poor.The lesions subsided after treated with rituximab injection combined glucocorticoid.

关 键 词：大疱性类天疱疮 利妥昔单抗 难治性 溃疡性结肠炎 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]