基于中国知网动脉粥样硬化动物实验的文献计量学分析  

Bibliometric Analysis of Animal Experiments Related to Atherosclerosis Literature Based on CNKI Database

作　　者：杨静 任星[2] 杨巧宁 张菀桐[2] 高蕊 YANG Jing;REN Xing;YANG Qiaoning;ZHANG Wantong;GAO Rui(Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China;Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中国中医科学院西苑医院,北京100091

出　　处：《世界中医药》2021年第23期3539-3544,共6页World Chinese Medicine

基　　金：国家“十三五”支撑计划项目(2017ZX09304003)——体现中药特点的重大疾病新药临床评价技术平台建设;国家重点研发计划“中医药现代化研究”项目(2019YFC1709300)——糖尿病足中西医结合防治方案的循证评价及疗效机制研究。

摘　　要：目的:分析动脉粥样硬化动物实验的研究现状,寻求公认的造模方法。方法:在国家知识基础设施数据库(简称中国知网,CNKI)中检索近10年内动脉粥样硬化相关动物实验的文献,按照发表时间、发文类型、文献来源、模型动物种类、造模方法、造模时间、涉及治疗方法等进行分析。结果:共纳入2709篇文献,1)涉及动脉粥样硬化治疗的文献有2173篇;2)发文趋势整体较平稳;3)模型动物以ApoE^(-/-)小鼠、SD大鼠、新西兰兔为主,其主要造模方法分别为单纯高脂饮食喂养、高脂饮食+腹腔注射维生素D_(3)、高脂饮食+球囊损伤;4)中医药治疗动脉粥样硬化的动物实验已广泛开展。结论:目前涉及最多的动物模型是ApoE^(-/-)小鼠,以单纯高脂饮食喂养为造模方法,造模时间集中在12周左右,且中医对于动脉粥样硬化的研究已深入开展,为其在临床中的广泛应用奠定基础。Objective:To analyze the current research status of atherosclerosis in animal experiments and seek a recognized method for modeling.Methods:The CNKI database was searched for the literature on atherosclerosis-related animal experiments in the past ten years,and analyzed according to the publication time,type of publication,document source,type of model animal,modeling method,modeling time,and related treatment methods.Results:A total of 2709 papers were included,1)2173 papers related to the treatment of atherosclerosis;2)The publishing trend was generally stable;3)Model animals were ApoE^(-/-) mice,SD rats,and New Zealand rabbits.Mainly,the main modeling methods were simple high-fat diet feeding,high-fat diet+intraperitoneal injection of vitamin D3,high-fat diet+balloon injury;4)Animal experiments on the treatment of atherosclerosis with traditional Chinese medicine have been widely carried out.Conclusion:At present,the most involved animal model is ApoE^(-/-) mice.The model is made by feeding pure high-fat diet.The modelling time is concentrated at about 12 weeks,and the research on atherosclerosis in Chinese medicine has been deeply carried out,which laid the foundation for wide application in clinic.

关 键 词：动脉粥样硬化 动物实验 造模方法 动物模型 APOE-/-小鼠 SD大鼠 新西兰兔 中医药 

分 类 号：R256.22[医药卫生—中医内科学]