中西医结合治疗冠心病(气阴两虚证)疗效的Meta分析  

Meta-analysis of Curative Effect of Integrated Traditional Chinese and Western Medicine on Coronary Heart Disease with Deficiency of Both Qi and Yin

作　　者：王凤儒[1] 徐京育[1] 杜琳 张晓琳[2] 孙阳[2] Wang Fengru;Xu Jingyu;Du Lin;Zhang Xiaolin;Sun Yang(The First Affiliated Hospital of Heilongjiang Liniversity of Traditional Chinese Medicine,Heilongjiang,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中国中医急症》2021年第12期2069-2073,2082,共6页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81704054);黑龙江省中医药科研项目(ZHY16-100)。

摘　　要：目的应用系统评价中西医结合治疗冠心病(气阴两虚证)的更优性。方法计算机搜索中国知网(CNKI)、万方数据库(WanFang Data)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Cochrane Library等数据库中有关于中西医结合治疗冠心病(气阴两虚证)的随机对照试验,检索的时限为建库至2020年12月15日。根据纳入标准和排除标准,由2名研究者筛选文献、提取临床资料、评价文献质量,采用Revman5.3软件分析,并用三线表显示中药的用药规律。结果最终筛选得到的15篇文献,经Meta分析后结果显示:中西医结合治疗冠心病(气阴两虚证)的临床疗效优于单纯的西药治疗,差异具有统计学意义[OR=3.90,95%CI(2.34,6.49),P<0.00001],另外实验组对于改善心电图[OR=2.58,95%CI(1.63,4.09),P<0.00001],改善心绞痛症状[OR=2.58,95%CI(1.63,4.09),P<0.00001],改善TC[OR=-0.38,95%CI(-0.58,-0.18),P=0.0002],LDL-C[OR=-0.29,95%CI(-0.45,-0.13),P=0.0004],HDL-C[OR=-0.26,95%CI(-0.04,0.56),P=0.09]方面均优于对照组,差异具有统计学意义。结论中西医结合治疗冠心病(气阴两虚证)在临床疗效、心电图疗效、改善心绞痛症状、改善血脂指标上比单纯西医治疗作用更好,具有很大的临床意义。Objective:To systematically evaluate the superiority of integrated traditional Chinese and western medicine in treating coronary heart disease with deficiency of both qi and yin.Methods:CNKI,WanFang Data,VIP,CBM,PubMed,Cochrane Library and other databases were searched for randomized controlled trials of treating coronary heart disease with deficiency of both qi and yin by integrated traditional Chinese and western medicine from inception to December 15 th,2020.According to the inclusion criteria and exclusion criteria,two researchers screened literature,extracted clinical data,evaluated the quality of literature,analyzed it with Revman5.3 software,and showed the medication rules of traditional Chinese medicine with three-line table.Results:After meta-analysis,the results of 15 selected literatures showed that the clinical efficacy of integrated traditional Chinese and western medicine in treating coronary heart disease with deficiency of both qi and yin was better than that of western medicine alone,and the difference was statistically significant[OR=3.90,95%CI(2.34,6.49),P<0.00001].In addition,the experimental group had a better effect on improving electrocardiogram[OR=2.58,95%CI(1.63,4.09),P<0.00001]and angina symptoms[OR=3.90,95%CI(2.16,7.06),P<0.00001].Levels of TC[OR=-0.38,95%CI(-0.58,-0.18),P=0.0002],LDL-C[OR=-0.29,95%CI(-0.45,-0.13),P=0.0004],and HDL-C[OR=-0.26,95%CI(-0.04,0.56),P=0.09]of the experimental group were superior to the control group,and the differences were statistically significant.Conclusion:The treatment of coronary heart disease with deficiency of both qi and yin by integrated traditional Chinese and western medicine has better clinical effect,electrocardiogram effect,improvement of angina pectoris symptoms and blood lipid index than that by western medicine alone,which has great clinical significance.

关 键 词：冠心病 中西医结合 气阴两虚型 随机对照试验 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]