EBV感染致传染性单核细胞增多症患儿外周血淋巴细胞亚群和免疫球蛋白变化研究  

Study on changes of peripheral blood lymphocyte subsets and immunoglobulins in children with infectious mononucleosis infected by Epstein-Barr virus

作　　者：刘晓宇 呼婵娟 张俊红 王凤昌 LIU Xiao-yu;HU Chan-juan;ZHANG Jun-hong;WANG Feng-chang(Department of Pediatrics,Chinese PLA Air Force Characteristic Medical Center,Beijing 100141,China)

机构地区：[1]解放军空军特色医学中心儿科,北京100141

出　　处：《传染病信息》2021年第6期545-548,共4页Infectious Disease Information

摘　　要：目的研究EBV感染致传染性单核细胞增多症(infectious mononucleosis,IM)患儿外周血淋巴细胞亚群和免疫球蛋白表达变化,为该病的临床诊治提供参考。方法选择2015年8月—2020年10月在我院诊治的42例EBV感染致IM患儿作为病例组,以年龄、性别相匹配的同期健康体检儿童42例作为对照组,空腹抽取外周静脉血检测2组血常规、B淋巴细胞、NK细胞、异型淋巴细胞比例、CD3+T淋巴细胞、CD4+T淋巴细胞、CD8+T淋巴细胞数量及IgA、IgG、IgM表达水平。结果病例组白细胞计数、淋巴细胞计数、异型淋巴细胞比例、异型淋巴细胞阳性率均显著高于对照组,差异有统计学意义(P均<0.05)。病例组B淋巴细胞计数低于对照组,CD3+、CD8+T淋巴细胞计数均高于对照组,差异有统计学意义(P均<0.05)。病例组IgA、IgG表达水平均显著高于对照组,差异有统计学意义(P均<0.05)。2组NK细胞、CD4+T淋巴细胞计数、IgM表达水平之间相比,差异均无统计学意义(P均>0.05)。结论儿童感染EBV致IM后机体会产生大量的T淋巴细胞,引起外周血中CD3+、CD8+T淋巴细胞计数升高,IgA、IgG表达水平随之升高,检测IM患儿外周血淋巴细胞亚群、异型淋巴细胞比例和免疫球蛋白表达变化对IM的诊断及治疗有一定的指导意义。Objective To study the changes of peripheral blood lymphocyte subsets and immunoglobulins in children with infectious mononucleosis(IM)infected by Epstein-Barr virus(EBV),and to provide references for clinical diagnosis and treatment of the disease.Methods Forty-two children with IM caused by EBV infection who were diagnosed and treated in our hospital from August 2015 to October 2020 were selected as the case group,and 42 age and gender matched children undergoing healthy physical examination during the same period were selected as the control group.Peripheral venous blood at fasting state was drawn for routine blood test.The proportion of B lymphocytes,NK cells,atypical lymphocytes,count of CD3+,CD4+,CD8+T lymphocytes,expression levels of IgA,IgG and IgM were determined.Results The white blood cell count,lymphocyte count,proportion of atypical lymphocytes,and the positive rate of atypical lymphocytes in the case group were significantly higher than those in the control group.The difference was statistically significant(P<0.05).The count of B lymphocytes in the case group was lower than that in the control group,while the counts of CD3+and CD8+T lymphocytes were higher than those in the control group.The difference was statistically significant(P<0.05).The expression levels of IgA and IgG in the case group were significantly higher than those in the control group.The differences were statistically significant(P<0.05).The counts of NK cells and CD4+T lymphocytes,as well as IgM expression in 2 groups showed no statistically significant differences(P>0.05).Conclusions After children have IM infected by EBV,the body will produce a large number of T lymphocytes,which will increase the counts of CD3+and CD8+T lymphocytes in peripheral blood and the expression levels of IgA and IgG will increase accordingly.Detecting the proportion of peripheral blood lymphocyte subsets,atypical lymphocytes and the expression changes of immunoglobulins in IM children has certain guiding significance for the diagnosis and treatment of I

关 键 词：EB病毒 儿童 单核细胞增多症 淋巴细胞亚群 免疫球蛋白 意义 

分 类 号：R512.7[医药卫生—内科学] R725.1[医药卫生—临床医学]