2009年至2021年我国9省份发热呼吸道症候群病例中人偏肺病毒感染情况及流行特征分析  

Viral infection and epidemiological characteristics of human metapneumovirus in febrile respiratory syndrome cases in nine provinces in China from 2009 to 2021

作　　者：崔爱利[1] 谢智博 余鹏博[2] 朱汝南[3] 马英伟[4] 向星宇[5] 张丽萍[6] 朱云 吴巨龙[8] 郜振国[9] 张荣波 韩光跃[11] 许文波[1] 张燕[1] Cui Aili;Xie Zhibo;Yu Pengbo;Zhu Runan;Ma Yingwei;Xiang Xingyu;Zhang Liping;Zhu Yun;Wu Julong;Gao Zhenguo;Zhang Rongbo;Han Guangyue;Xu Wenbo;Zhang Yan(NHC Key Laboratory of Medical Virology and Viral Diseases,World Health Organization Western Pacific Regional Office Regional Reference Laboratory of Measles and Rubella,Measles Laboratory in National Institute for Viral Disease Control and Prevention,Chinese Centers for Disease Control and Prevention,Beijing 102206,China;Department of Viral Disease,Shaanxi Center for Disease Control and Prevention,Xi′an 710054,China;Laboratory of Virology,Beijing Key Laboratory of Etiology of Viral Diseases in Children,Capital Institute of Pediatrics,Beijing 100020,China;Precision Medicine Research Center,Children′s Hospital of Changchun,Changchun 130061,China;Department of Microbiological Examination,Hunan Center for Disease Control and Prevention,Changsha 410005,China;Institute of Health Inspection and Quarantine,Chinese Academy of Inspection and Quarantine,Beijing 100176,China;Laboratory of Infection and Virology,Beijing Pediatric Research Institute,Beijing Children′s Hospital,Capital Medical University,Beijing 100045,China;Department of Viral Diseases,Institute for Communicable Disease Control and Prevention,Shandong Center for Di-sease Control and Prevention,Jinan 250014,China;Institute for Infectious Disease Prevention and Treatment,Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention,Urumchi 830002,China;Department of Immuno-logy,School of Medicine,Anhui University of Science and Technology,Huainan 232001,Anhui Province,China;Institute for Prevention and Control of Viral Diseases,Hebei Center for Disease Control and Prevention,Shijiazhuang 050021,China)

机构地区：[1]国家卫生健康委员会医学病毒和病毒病重点实验室,世界卫生组织西太平洋地区麻疹/风疹参比实验室,中国疾病预防控制中心病毒病预防控制所麻疹室,北京102206 [2]陕西省疾病预防控制中心病毒病科,西安710054 [3]首都儿科研究所病毒研究室,儿童病毒病病原学北京市重点实验室,北京100020 [4]长春市儿童医院精准医学研究中心,长春130061 [5]湖南省疾病预防控制中心微生物检验科,长沙410005 [6]中国检验检疫科学研究院卫生检验与检疫研究所,北京100176 [7]首都医科大学附属北京儿童医院,北京市儿科研究所感染与病毒研究室,北京100045 [8]山东省疾病预防控制中心传染病预防控制所病毒病科,济南250014 [9]新疆维吾尔自治区疾病预防控制中心传染病防治所,乌鲁木齐830002 [10]安徽理工大学医学院免疫学教研室,安徽淮南232001 [11]河北省疾病预防控制中心病毒病防治所,石家庄050021

出　　处：《中华实用儿科临床杂志》2021年第24期1861-1865,共5页Chinese Journal of Applied Clinical Pediatrics

基　　金：国家科技重大专项课题(2018ZX10713002,2018ZX10713001-003)。

摘　　要：目的阐明我国发热呼吸道症候群(FRS)监测病例中人偏肺病毒(HMPV)感染情况及病毒流行特征,为我国HMPV引起呼吸道相关疾病的临床诊治和疾病防控提供重要基线数据。方法选取2009年1月至2021年6月在我国9省份(北京、河北、吉林、山东、陕西、新疆、安徽、广东、湖南)的FRS监测病例作为研究对象。收集病例临床、流行病学信息并采集呼吸道标本,应用实时荧光定量PCR对样本进行HMPV核酸检测。结果共11660例样本进行了HMPV检测,HMPV阳性病例数为296例,阳性检出率为2.54%。其中218例病例为单一HMPV感染,78例病例同时检出了含HMPV 2种或2种以上病毒,占HMPV阳性病例数的26.35%。<5岁儿童是HMPV主要发病人群,检出率为3.10%。在<5岁儿童中,含HMPV混合感染中肺炎病例的比例高于单一HMPV感染病例。HMPV全年均可检出,病毒流行主要以冬、春季为主,3月份是HMPV流行高峰。结论HMPV是引起儿童急性呼吸道感染的重要病原之一,病毒流行具有明显的季节性。HMPV可引起单独感染,也可与其他呼吸道病毒合并感染,合并HMPV感染可能增加儿童肺炎的风险。Objective To clarify the infection and epidemic characteristics of the human metapneumovirus(HMPV)in Chinese patients with febrile respiratory syndrome(FRS),and to provide important baseline data for clinical diagnosis,treatment,prevention and control of HMPV-induced respiratory tract diseases in China.Methods FRS cases from January 2009 to June 2021 in 9 provinces in China,including Beijing,Hebei,Jilin,Shandong,Shaanxi,Xinjiang,Anhui,Guangdong,Hunan were retrospectively analyzed for their respiratory samples,clinical and epidemic data.The respiratory samples were detected for HMPV by quantitative real-time PCR.Results A total of 11660 cases were tested for HMPV,involving 296(2.54%)HMPV-positive cases.Among 296 HMPV-positive cases,218 were single HMPV infection,and 78/296(26.35%)were co-infected with one or more respiratory viruses.HMPV mainly affected children under 5 years of age(3.10%),and in this population,the proportion of pneumonia in HMPV co-infection cases was significantly higher than that of single HMPV infection.HMPV could be detected all year round,which was more popular in winter and spring,with the peak of HMPV epidemic in March.Conclusions HMPV is one of the important pathogens causing acute respiratory infection in children,showing a clear seasonal epidemic.HMPV can be infected alone or in combination with other respiratory viruses,which may increase the risk of pneumonia in children.

关 键 词：发热呼吸道症候群 人偏肺病毒感染 流行特征 

分 类 号：R725.6[医药卫生—儿科] R181.3[医药卫生—临床医学]