Transfusion-transmitted hepatitis E:What we know so far?  

作　　者：Carmen Ka Man Cheung Sunny Hei Wong Alvin Wing Hin Law Man Fai Law 

机构地区：[1]Medicine and Therapeutics,Prince of Wales Hospital,Hong Kong 852,China [2]Institute of Digestive Disease and Department of Medicine and Therapeutics,the Chinese University of Hong Kong,Hong Kong 852,China [3]Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore 639798,Singapore [4]West Island School,Hong Kong 852,China

出　　处：《World Journal of Gastroenterology》2022年第1期47-75,共29页世界胃肠病学杂志（英文版）

摘　　要：Hepatitis E virus(HEV)is a major cause of viral hepatitis globally.There is growing concern about transfusion-transmitted HEV(TT-HEV)as an emerging global health problem.HEV can potentially result in chronic infection in immunocompromised patients,leading to a higher risk of liver cirrhosis and even death.Between 0.0013%and 0.281%of asymptomatic blood donors around the world have HEV viremia,and 0.27%to 60.5%have anti-HEV immunoglobulin G.HEV is infectious even at very low blood concentrations of the virus.Immunosuppressed patients who develop persistent hepatitis E infection should have their immunosuppressant regimen reduced;ribavirin may be considered as treatment.Pegylated interferon can be considered in those who are refractory or intolerant to ribavirin.Sofosbuvir,a nucleotide analog,showed modest antiviral activity in some clinical studies but sustained viral response was not achieved.Therefore,rescue treatment remains an unmet need.The need for HEV screening of all blood donations remains controversial.Universal screening has been adopted in some countries after consideration of risk and resource availability.Various pathogen reduction methods have also been proposed to reduce the risk of TT-HEV.Future studies are needed to define the incidence of transmission through transfusion,their clinical features,outcomes and prognosis.

关 键 词：Hepatitis E virus Acute and chronic hepatitis IMMUNOSUPPRESSION Blood transfusion TRANSPLANTATION 

分 类 号：R512.6[医药卫生—内科学]