生物基聚乳酸复合材料3D打印制备含微孔支架及性能研究  

Preparation and properties of microporous scaffolds by 3D printing of bio-based polylactic acid composites

作　　者：覃柳琪 董先明 苏祥郁 周武艺 郑文旭 QIN Liuqi;DONG Xianming;SU Xiangyu;ZHOU Wuyi;ZHENG Wenxu(Key laboratory of Bio-based Materials and Energy,Ministry of Education,Guangzhou 510642,China;College of Materials and Energy,South China Agricultural University,Guangzhou 510642,China)

机构地区：[1]生物基材料与能源教育部重点实验室,广东广州510642 [2]华南农业大学材料与能源学院,广东广州510642

出　　处：《华南农业大学学报》2022年第1期37-43,共7页Journal of South China Agricultural University

基　　金：广东省科技厅国际合作项目(2020A0505100050);广东省自然科学基金(2020A1515011004);广东普通高校新冠肺炎疫情防控科研专项(2020KZDZX1035)。

摘　　要：【目的】探讨生物基聚乳酸复合材料用于3D打印直接构建含微孔支架的可行性。【方法】采用热重分析仪和差示扫描量热仪探究聚乳酸复合材料的热性能,扫描电镜表征支架的微观形貌,活/死细胞染色检测支架的细胞黏附情况。【结果】所制备的0.6%ADC-PHAP和40%NaCl-PHAP复合材料具有良好的热稳定性和加工性,适用于熔融沉积3D打印。当压缩应变为80%时,0.6%ADC-PHAP和40%NaCl-PHAP支架相应的压缩应力分别为45.27和52.11 MPa;0.6%ADC-PHAP复合材料的初始分解温度比40%NaCl-PHAP复合材料低19.5℃;0.6%ADC-PHAP支架的孔隙率达到63.33%,有利于细胞黏附,且细胞相容性比40%NaCl-PHAP支架更好。【结论】生物基聚乳酸复合材料可通过熔融沉积型3D打印直接构建含微孔支架,所制备的0.6%ADC-PHAP支架具有一定的应用潜力。【Objective】To explore the feasibility of using bio-based polylactic acid composites to directly construct microporous scaffolds by 3D printing.【Method】Thermogravimetric analyzer and differential scanning calorimeter were used to explore the thermal properties of bio-based polylactic acid composites,scanning electron microscopy was used to characterize the microscopic morphology of the bio-scaffold,and the live/dead cell staining was used for detecting cell adhesion of the scaffold.【Result】The prepared 0.6%ADC-PHAP and 40%NaCl-PHAP composites had good thermal stability and processability,and were suitable for the fused deposition modeling 3D printing process.When the compressive strain was 80%,the corresponding compressive stresses of the 0.6%ADC-PHAP and 40%NaCl-PHAP scaffolds were 45.27 and 52.11 MPa,respectively.The initial decomposition temperature of the 0.6%ADC-PHAP composite was 19.5℃lower than that of the 40%NaCl-PHAP composite.The porosity of the 0.6%ADC-PHAP scaffold reached 63.33%which was conducive to cell adhesion,and the cell compatibility was better than that of the 40%NaCl-PHAP scaffold.【Conclusion】The bio-based polylactic acid composites can be used to directly construct microporous bio-scaffolds through fused deposition modeling 3D printing,and the prepared 0.6%ADC-PHAP bio-scaffold has certain application potential.

关 键 词：熔融共混 3D打印 支架 聚乳酸 生物基材料 

分 类 号：S511[农业科学—作物学] S502