天保宁联合阿托伐他汀对冠心病心绞痛患者血脂代谢及炎性因子水平的影响  

Effects of Tebonin combined with atorvastatin on lipid metabolism and inflammatory factors in patients with coronary heart disease and angina pectoris

作　　者：李清 朱夏青 杨华俊 吴小洪 梁桂英 LI Qing;ZHU Xiaqing;YANG Huajun;WU Xiaohong;LIANG Guiying(Department of Pharmacy,The First People's Hospital of Fuyang District,Hangzhou 311400,China;Department of Cardiology,The First People's Hospital of Fuyang District,Hangzhou 311400,China)

机构地区：[1]浙江省杭州市富阳区第一人民医院药剂科,杭州311400 [2]浙江省杭州市富阳区第一人民医院心血管内科,杭州311400

出　　处：《中国临床药学杂志》2021年第6期401-405,共5页Chinese Journal of Clinical Pharmacy

基　　金：杭州市医药卫生科技项目(编号B20200260)。

摘　　要：目的探究天保宁联合阿托伐他汀对冠心病心绞痛患者血脂代谢及炎性因子水平的影响。方法选择2018年6月至2019年12月于本院就诊的158例冠心病心绞痛患者,随机分为对照组(n=79)和观察组(n=79)。对照组予阿托伐他汀治疗,观察组予阿托伐他汀联合天保宁治疗。对2组临床疗效、心功能、血脂水平及不良反应发生情况进行比较。结果治疗后,观察组临床疗效总有效率显著高于对照组(92.41%vs 81.01%,P<0.05);2组心功能[左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)],血脂[胆固醇(TC)、三酰甘油(TAG)、低密度脂蛋白胆固醇(LDL-C)]及炎症指标[高速泳动族蛋白B1(HMGB1)、白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]水平显著低于治疗前,而心功能[左心室射血分数(LVEF)]、血脂[高密度脂蛋白胆固醇(HDL-C)]水平显著高于治疗前(P<0.05),且观察组心功能、血脂及炎症反应改善情况较对照组更加显著(P<0.05)。治疗期间,2组不良反应发生率经比较,差异无统计学意义(χ^(2)=0.313,P=0.516)。结论天保宁联合阿托伐他汀治疗冠心病心绞痛,可明显改善患者的临床疗效及心功能,降低其血脂水平及炎症反应。AIM To explore the effects of Tebonin combined with atorvastatin on lipid metabolism and inflammatory factors in patients with coronary heart disease and angina pectoris.METHODS A total of 158 patients with coronary heart disease and angina pectoris treated in our hospital from June 2018 to December 2019 were randomly divided into control group(n=79)and observation group(n=79).The control group was treated with atorvastatin,and the observation group was treated with Tebonin on the basis of the control group.The clinical efficacy,cardiac function,blood lipid levels and adverse drug reactions were compared and analyzed between 2 groups.RESULTS After treatment,the total effective rate of clinical efficacy in the observation group(92.41%)was significantly higher than that in the control group(81.01%,P<0.05);the levels of cardiac function[left ventricular end-systolic dimension(LVESD),left ventricular end diastolic dimension(LVEDD)],blood lipid levels[cholesterol(TC),triacylglycerol(TAG),low density lipoprotein cholesterol(LDL-C)]and inflammatory indexes[high mobility group protein box 1(HMGB1),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP)]in 2 groups were significantly lower than those before treatment,the cardiac function[left ventricular ejection fraction(LVEF)]and blood lipid levels[high density lipoprotein cholesterol(HDL-C)]were significantly higher than those before treatment(P<0.05),and the improvement of cardiac function,blood lipid and inflammatory reaction in the observation group was more significant than that in the control group(P<0.05).During treatment,the incidence of adverse reactions between 2 groups was not statistically significant(χ^(2)=0.313,P=0.516).CONCLUSION Tebonin combined with atorvastatin in the treatment of patients with coronary heart disease and angina pectoris can significantly improve the clinical efficacy and cardiac function,and reduce the levels of blood lipid and inflammation reaction.

关 键 词：天保宁 阿托伐他汀 冠心病 心绞痛 血脂代谢 炎性因子 

分 类 号：R541.4[医药卫生—心血管疾病]