外消旋化合物生物催化去对称化研究进展  

Research Progress in Biocatalytic Desymmetrization of Racemic Compounds

作　　者：苏亚民 戴大章 SU Ya-min;DAI Da-zhang(School of Chemistry and Chemical Engineering,Beijing Institute of Technology,Beijing 100081)

机构地区：[1]北京理工大学化学与化工学院,北京100081

出　　处：《分子催化》2021年第5期471-483,I0004,共14页Journal of Molecular Catalysis(China)

基　　金：国家自然科学基金(21276025,21808004)。

摘　　要：手性化合物外消旋体的生物催化去对称化是目前生物与有机合成领域的重点、难点和热点,也是制备光学纯手性化合物的重要途径.我们将近年来发展起来的手性化合物生物催化去对称化的方法归纳为立体转化去对称化法、线性去对称化法、循环去对称化法、对映体收敛去对称化法和一步去对称化法5大类,对这些方法的原理、特点及其应用进展分别进行介绍,并对其未来发展趋势进行展望.The biocatalytic desymmetrization of racemates of chiral compounds is the focus, difficulty and hotspot in the field of biological and organic synthesis currently, and it is also an important way to prepare optically pure chiral compounds. In this paper, the methods for biocatalytic desymmetrization of chiral compounds developed in recent years are summarized as desymmetrization by stereoinversion, linear desymmetrization, cyclic desymmetrization, enantioconvergent process desymmetrization and one-step desymmetrization. The principles, characteristics and application progress of these methods are respectively introduced and their future development trends are prospected.

关 键 词：手性化合物 外消旋体 生物催化 去对称化 

分 类 号：O643.32[理学—物理化学] O622.5[理学—化学]