Paradoxical role of interleukin-33/suppressor of tumorigenicity 2 in colorectal carcinogenesis: Progress and therapeutic potential  

作　　者：Fang Huang Wan-Yuan Chen Jie Ma Xiang-Lei He Jian-Wei Wang 

机构地区：[1]Department of Pathology,Laboratory Medicine Center,Zhejiang Provincial Peoples’Hospital,Peoples’Hospital of Hangzhou Medical College,Hangzhou 310014,Zhejiang Province,China [2]Key Laboratory of Endocrine Gland Diseases of Zhejiang Province,Peoples’Hospital of Hangzhou Medical College,Hangzhou 310014,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2022年第1期23-34,共12页世界临床病例杂志

基　　金：Natural Science Foundation of China,No.81803069;Zhejiang Medical Technology Plan Project,No.2019RC007,No.2019KY007 and No.2021KY047;Funds of Science Technology Department of Zhejiang Province,No.LGF21H160033.

摘　　要：Colorectal cancer(CRC)is presently the second most prevalent global mortalityinducing cancer.CRC carcinogenesis is a multifactorial process involving internal genetic mutations and the external environment.In addition,non-neoplastic cell activities within tumor microenvironments for CRC development have been established.However,interleukin(IL)-33,secreted by such cell types,plays a pivotal role in cancer progression due to interaction with cellular constituents within the tumor-inflammation microenvironment.IL-33 belongs to the IL-1 cytokine family and acts as binding attachments for the suppressor of tumorigenicity(ST)2 receptor.Therefore,how to coordinate tumor microenvironment,design and optimize treatment strategies suitable for CRC,based on IL-33/ST2 signal is a challenge.Even though it has established influences upon immunitylinked conditions,IL-33 effects on CRC progression and prevention and related mechanisms are still controversial.Our review depicts controversial activities for IL-33/ST2 within carcinogenesis and cancer prevention.Moreover,IL-33/ST2 signaling is a potential therapeutic target for CRC.

关 键 词：Interleukin 33 Suppressor of tumorigenicity 2 signaling Tumor microenvironment Conventional therapies Colorectal cancer 

分 类 号：R735.34[医药卫生—肿瘤]