Alterations in blink and masseter reflex latencies in older adults with neurocognitive disorder and/or diabetes mellitus  

作　　者：Jaime Alberto Bricio-Barrios Eder Ríos-Bracamontes Mónica Ríos-Silva Miguel Huerta Walter Serrano-Moreno JoséEnrique Barrios-Navarro Genaro Gabriel Ortiz Miguel Huerta-Trujillo JoséGuzmán-Esquivel Xóchitl Trujillo 

机构地区：[1]Faculty of Medicine,University of Colima,Colima 28040,Colima,Mexico [2]General Hospital Zone#1,Mexican Social Security Institute,Villa de Alvarez 28983,Colima,Mexico [3]University Biomedical Research Center,University of Colima,Colima 28045,Colima,Mexico [4]University Biomedical Research Center,CONACYT,Colima 28045,Colima,Mexico [5]Department of Philosophical and Methodological Disciplines,University Health Sciences Center,University of Guadalajara,Guadalajara 44340,Jalisco,Mexico

出　　处：《World Journal of Clinical Cases》2022年第1期177-188,共12页世界临床病例杂志

摘　　要：BACKGROUND Blink and masseter reflexes provide reliable,quantifiable data on the function of the central nervous system:Delayed latencies have been found in patients with neurocognitive disorder(ND)and type 2 diabetes mellitus(T2DM),but this has not been studied in patients with both pathologies.AIM To investigate if older adults with ND plus T2DM have prolonged latencies of blink and masseter-reflex and if they were associated with disease progression.METHODS This cross-sectional study included 227 older adults(>60 years)from Colima,Mexico.Neurocognitive disorder was identified by a neuropsychological battery test,and T2DM identified by medical history,fasting glucose,and glycosylated hemoglobin.Latencies in the early reflex(R1),ipsilateral late(R2),and contralateral late(R2c)components of the blink reflex were analyzed for all subjects,and 183 subjects were analyzed for latency of the masseter reflex.RESULTS In 20.7%of participants,ND was detected.In 37%,T2DM was detected.Latencies in R1,R2,and R2c were significantly prolonged for groups with ND plus T2DM,ND,and T2DM,compared with the control group(P<0.0001).The masseter reflex was only prolonged in older adults(regardless of T2DM status)with ND vs controls(P=0.030).In older adults with ND and without T2DM,the more the cognitive impairment progressed,the more prolonged latencies in R2 and R2c presented(P<0.01).CONCLUSION These findings suggest that blink and masseter reflexes could be used to evaluate possible changes in brainstem circuits in older adults with ND and T2DM.

关 键 词：Blink reflex Masseter reflex Brainstem reflexes Neurocognitive disorder Type 2 diabetes mellitus Older adults 

分 类 号：R587.2[医药卫生—内分泌] R749.1[医药卫生—内科学]