基于相控阵聚焦的经颅磁声电刺激仿真与实验分析  

Simulation and experimental analysis of transcranial magneto-acoustic electrical stimulation based on phased-array focusing

作　　者：张帅[1,2] 李梦迪 王艺潇 焦立鹏 徐桂芝[1,2] Zhang Shuai;Li Mengdi;Wang Yixiao;Jiao Lipeng;Xu Guizhi(State Key Laboratory of Reliability and Intelligence of Electrical Equipment,Hebeil University of Technology,Tianjin 300130,China;Hebei Key Laboratory of Bioelectromagnetic and Neural Engineering,Hebeil University of Technology,Tianjin 300130,China)

机构地区：[1]河北工业大学省部共建电工装备可靠性与智能化国家重点实验室,天津300130 [2]河北工业大学河北省生物电磁与神经工程重点实验室(筹),天津300130

出　　处：《电子测量技术》2021年第20期107-112,共6页Electronic Measurement Technology

基　　金：国家自然科学基金面上项目(51877069)资助。

摘　　要：经颅磁声电刺激方法在颅内产生的感应电场分布是决定神经调控精度的关键因素。相控阵可产生高聚焦度声场,但其结构参数与颅内感应电场之间关系尚不明确。本文建立了包含相控阵的三维有限元模型,计算了声场分布并采用焦区横截面积、焦区深度、声强和电场强度为评价指标。设计仿体实验测量了焦点处实际电场强度。以Wistar大鼠为实验对象,考察了相控阵在0.8MHz中心频率,不同阵元数下与0.3T静磁场耦合作用对大鼠局部场电位的作用规律。结果表明,增加阵元数目可提高焦区电场强度,进而降低局部场电位低频段(4~30Hz)振荡频率,增加高频段(30~80Hz)能量,揭示了基于相控阵聚焦的经颅磁声电刺激对神经元兴奋性的调节机制,为经颅磁声电刺激系统设计与相控阵结构参数选择提供参考。The distribution of the induced electric field generated intracranially by transcranial magneto-acoustic electrical stimulation is a key factor in determining the accuracy of neuromodulation.Phased arrays can generate highly focused acoustic fields,but the relationship between their structural parameters and intracranial induced electric fields is unclear.A threedimensional finite element model containing the phased array was developed,and the acoustic field distribution was calculated and evaluated by using the cross-sectional area of the focal zone,the depth of the focal zone,the acoustic intensity and the electric field strength.The actual electric field intensity at the focal area was measured by designing a mimic experiment.The effect of the phased array on the local field potential of rats at 0.8 MHz center frequency with different number of array elements coupled with 0.3Tstatic magnetic field was investigated using Wistar rats as the experimental object.The results showed that increasing the number of array elements could increase the electric field intensity in the focal area,and then decrease the oscillation frequency in the low frequency band(4~30Hz)and increase the energy in the high frequency band(30~80Hz),which revealed the mechanism of neuronal excitability regulation by phased array-based focused transcranial magnetoacoustic stimulation,and provided a reference for the design of transcranial magnetoacoustic stimulation system and the selection of phased array structure parameters.

关 键 词：经颅磁声电刺激 相控阵 时频分析 放电节律 

分 类 号：TM12[电气工程—电工理论与新技术]